PSf-CA中空纤维血液透析共混膜的制备及性能  

Preparation and performance of PSf-CA hollow fiber hemodialysis blend membrane

作　　者：潘振强[1] 许敏贤[1] 马晓华[1] 魏永明[1] 许振良[1] 徐孙杰 PAN Zhenqiang XU Minxian MA Xiaohua WEI Yongming XU Zhenliang XU Sunjie(State Key Laboratory of Chemical Engineering, Membrane Science and Engineering R＆D Lab, Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237, Chin)

机构地区：[1]化学工程联合国家重点实验室华东理工大学化学工程研究所膜科学与工程研发中心,上海200237

出　　处：《膜科学与技术》2017年第3期53-61,共9页Membrane Science and Technology

基　　金：上海市科委产业支撑项目(13521102000)

摘　　要：以聚砜(PSf)和醋酸纤维素(CA)为膜材料,一缩二乙二醇(DEG)为添加剂,聚乙烯吡咯烷酮(PVP-K30)为改性剂,N,N-二甲基乙酰胺(DMAc)为溶剂,采用非溶剂致相分离法(NIPS)制备PSf-CA中空纤维血液透析膜,表征膜的微观结构、亲水性、渗透性能、溶质清除率以及机械性能,讨论不同共混比和不同品牌聚砜对PSf-CA中空纤维膜性能的影响,以及不同模拟液流速和不同透析液流速对溶质清除的影响.结果表明:当PSf(质量分数19%)与CA(质量分数2%)总量(质量分数)21%、PVP-K30(质量分数)10%和DMAc/DEG质量比5/1为铸膜液体系时,PSf-3所制备的膜具有最佳的透析性能,其超滤系数为1 695mL/(m^2·h·kPa),对肌酐、磷酸氢二钠、维生素B_(12)的清除速率分别为116 mL/min、115 mL/min和105mL/min,断裂强度为5.65 MPa.Polysulfone （PSf）-cellulose acetate （CA） hollow fiber hemodialysis membranes were prepared by nonsolvent induced phase separation （NIPS） method using PSf and CA as membrane materials, diethylene glycol （DEG） as the additive, polyvinyl pyrrolidone （PVP- K30） as the modification agent and dimethylacetamide （DMAc） as a solvent. The morphology, hydrophilicity, permeation performance, solute clearance and mechanical strength of the PSf- CA hollow fiber hemodialysis membranes were characterized. The effects of different blending ratios and the PSf from different companies on the properties of PSf- CA hollow fiber hemodialysis membranes, and the effects of different speeds for simulated solution and different speeds for dialysis solution on solute clearance were discussed. The experimental results showed that the suitable conditions of the casting solutions were as follows： mass fraction 21% PSf（19%）-CA（2%）, 10% PVP and DMAc/DEG mass ratio 5/1 while PSf-CA hollow fiber hemodialysis membrane fabricated from PSf- 3 had best hemodialysis properties, in which the ultrafiltration coefficients and clearance speeds of creatine, disodium hydrogen phosphate and VB12, and break strength reached 1 695 mL/（m2 · h · kPa） and 116 mL/min, 115 mL/min, 105 mL/min, and 5.65 MPa, respectively.

关 键 词：聚砜 醋酸纤维素 中空纤维 血液透析 制备 表征 

分 类 号：R318.08[医药卫生—生物医学工程] TQ051.893[医药卫生—基础医学]