青龙衣中抗肿瘤活性物质1-(4′-甲氧基苯基)-7-(3″-羟基苯基)-3′,4″-环氧-3-庚醇的全合成  

Anti-tumor active substance in pericarpium juglandis 1-(4′-methoxyphenyl)-7-(3″-hydroxyphenyl)-3′,4″-epoxy-3-heptaminol from natural products

作　　者：刘嘉琪[1] 付蕾[1] 富波[1] 张春晶[1] 贾力维[1] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《化学工程师》2017年第6期69-72,共4页Chemical Engineer

基　　金：黑龙江中医药大学科研基金面上项目(201738);黑龙江中医药大学教育教学研究基金项目(2015007);黑龙江省高等教育学会"十三五"高等教育科研课题(16Q110)

摘　　要：目的:合成抗肿瘤活性物质1-(4′-甲氧基苯基)-7-(3″-羟基苯基)-3′,4″-环氧-3-庚醇。方法:采用羟醛缩合、催化氢化和Williamson等化学反应合成目标产物。结果:完成了从青龙衣抗肿瘤活性部位分离得到的环状二芳基庚烷类化合物1-(4′-甲氧基苯基)-7-(3″-羟基苯基)-3′,4″-环氧-3-庚醇的首次全合成,产物结构经IR、~1H-NMR、^(13)C-NMR和MS进行了确证。结论合成目标产物的试剂廉价易得,方法简便高效。Objective：Synthetic antitumor active substances 1-（4′-methoxyphenyl）-7-（3″-hydroxyphenyl）-3′,4″-epoxy-3-heptaminol.Methods：The target products were synthesized by hydroxyaldehyde condensation,catalytic hydrogenation and Williamson.Results：From pericarpium juglandis antitumor active site of circular diaryl heptane compounds were isolated from 1-（4′-methoxyphenyl）-7-（3″-hydroxyphenyl）-3′,4″-epoxy-3-heptaminol fully synthetic heptanol,product structure by IR,~1H-NMR、^（13）C-NMR and MS.Conclusion The reagent of the resultant product is cheap and easy to use,and the method is simple and efficient.

关 键 词：环状二芳基庚烷类化合物 1-(4′-甲氧基苯基)-7-(3″-羟基苯基)-3′ 4″-环氧-3-庚醇 全合成 

分 类 号：R284[医药卫生—中药学]