1-氨基蒽醌的连续化合成方法研究  

Flow Synthesis of 1-Aminoanthraquinone

作　　者：胡博淳 陈晓禹[1] 丁振中 张超 王文龙[1] 

机构地区：[1]江南大学药学院,江苏无锡214122 [2]扬州日兴生物科技股份有限公司,江苏扬州225601

出　　处：《广州化工》2017年第12期29-30,共2页GuangZhou Chemical Industry

基　　金：江苏省政策引导类计划(No:BY2016022-37)

摘　　要：1-氨基蒽醌是合成蒽醌染料的重要中间体,在染料工业中占据极其重要的地位。本文发展了一种连续催化氢化制备1-氨基蒽醌的合成方法,分别以80℃为最佳反应温度,80 s为最佳保留时间以及1%的氨水作为最佳碱性溶液的最优条件,不但反应生成的1-氨基蒽醌的产率达到最高为95%,该方法不仅获得了传统方法的产率,而且为解决传统生产方法存在的污染严重和安全性差等问题提供了新思路。1-Aminoanthraquinone, which is widely used in the dye industry, is an important intermediate for the synthesis of anthraquinone dyes. To offer an environmental friendly method, flow chemistry was used to synthesize 1 - aminoanthraquinone with the optimized reaction conditions including 80℃C as reaction temperature, 80 s as retention time and ammonia as alkaline. The results indicated that the new protocol not only produced 1-aminoanthraquinone with the similar yield to batch chemistry, but provided new opportunity to figure out the environmental issues from batch chemistry.

关 键 词：1-氨基蒽醌 连续流微反应器 安全高效 绿色 

分 类 号：TQ463.4[化学工程—制药化工]