NOD蛋白与免疫应答  

NOD proteins and immune response

作　　者：沈雪莹[1] 方传雷 刘志华[1] SHEN Xue-Ying FANG Chuan-Lei LIU Zhi-Hua(CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 , China)

机构地区：[1]中国科学院生物物理研究所,中科院感染与免疫重点实验室,北京100101

出　　处：《中国免疫学杂志》2017年第6期801-810,共10页Chinese Journal of Immunology

摘　　要：NOD蛋白包括NOD1和NOD2,两者识别细菌肽聚糖的片段,诱导促炎和抗菌反应。在本篇综述中,我们介绍近年来NOD蛋白的研究进展,包括激活的方式,信号途径的调节,在细胞中的定位以及在免疫防御过程中发挥的作用。洞悉NOD蛋白诱导的信号通路有助于了解相关疾病的致病机理,为疾病的治疗提供新的视角。The NOD protein family include NODI and NOD2,both of which recognize intraecllular bacterial peptidoglycan, induce inllammation and promote host defense. In this review article, we summarize the research progress on NOD family, including signaling and regulation. We will also discuss their cellular localization and the role in host defense. Understanding on their physiological function will help shed light on pathogenesis on related diseases.

关 键 词：NOD蛋白 胞内定位 生理功能 

分 类 号：R392.1[医药卫生—免疫学]