微创血肿清除术联合神经生长因子制剂对高血压脑出血患者神经功能损伤的影响  

Influence of minimally invasive hematoma evacuation combined with nerve growth factor preparation on neurological function injury in patients with hypertensive cerebral hemorrhage

作　　者：江涛[1] 冯爱平[1] 刘伦波[1] 黄其军[1] 杜陈[1] 

机构地区：[1]四川省德阳市第二人民医院神经外科,四川德阳618000

出　　处：《海南医学院学报》2017年第10期1352-1354,1358,共4页Journal of Hainan Medical University

基　　金：德阳市科技局科研项目(DYCC20160054)~~

摘　　要：目的:探讨微创血肿清除术联合神经生长因子制剂对高血压脑出血患者神经功能损伤的影响。方法:收集本院收治的高血压脑出血患者112例,按照随机数表法分为接受微创血肿清除术治疗的对照组、接受微创血肿清除术联合神经生长因子制剂治疗的观察组各56例。治疗前后对比两组血清中炎症介质、神经损伤指标、神经递质含量的差异。结果:治疗前,两组血清中炎症介质、神经损伤指标、神经递质含量的差异无统计学意义(P>0.05)。治疗后,观察组血清中炎症介质CRP、PCT、IL-1β、IL-6的含量低于对照组;血清中神经损伤指标NSE、S100B、GEAP、MBP的含量低于对照组;血清中神经递质SP、NPY、Glu、Asp的含量低于对照组,GABA、Gly的含量高于对照组(P<0.05)。结论:微创血肿清除术联合神经生长因子制剂可有效减轻患者的神经功能损伤,具有积极的临床意义。Objective： To study the influence of minimally invasive hematoma evacuation combined with nerve growth factor preparation on neurological function injury in patients with hypertensive cerebral hemorrhage.Methods： A total of 112 patients with hypertensive cerebral hemorrhage who were treated in our hospital between July 2013 and February 2016 were collected, and according to random number table, they were divided into the control group （n=56） who underwent minimally invasive hematoma evacuation therapy and the observation group （n=56） who underwent minimally invasive hematoma evacuation combined with nerve growth factor preparation therapy.Serum contents of inflammatory mediators, nerve injury indexes and neurotransmitters were compared between two groups of patients before and after treatment.Results： Before treatment, there were no significant differences in serum contents of inflammatory mediators, nerve injury indexes and neurotransmitters between the two groups （P＆gt;0.05）.After treatment, serum contents of inflammatory mediators such as CRP, PCT, IL-1β and IL-6 in observation group were lower than those in control group;serum contents of nerve injury indexes such as NSE, S100B, GEAP and MBP were lower than those in control group;serum contents of neurotransmitters such as SP, NPY, Glu and Asp were lower than those in control group while GABA and Gly were higher than those in control group （P〈0.05）.Conclusions： Minimally invasive hematoma evacuation combined with nerve growth factor preparation can effectively reduce neurological function injury, and has positive clinical significance.

关 键 词：高血压脑出血 微创血肿清除术 神经生长因子 神经功能损伤 

分 类 号：R722.151[医药卫生—儿科]