朱红膏治疗慢性皮肤溃疡血尿汞浓度波动的临床研究  

Clinical Study on Mercury Concentration Fluctuations in the Blood and Serum of the Patients with Chronic Skin Ulcer Treated by ZhuHong Ointment

作　　者：孔晓丽[1] 徐旭英[1] 

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《西部中医药》2017年第5期79-82,共4页Western Journal of Traditional Chinese Medicine

基　　金：北京市科委首都特色项目(编号Z121107001012103);北京市卫生系统高层次卫生技术人才(学科骨干)项目(编号2013-3-080);北京市中医药管理局中医外治法专项(编号WZF2012-02);北京市卫生局"十百千"人才项目(编号2012-18)

摘　　要：目的:探讨汞离子在人体内的吸收与排泄过程。方法:将慢性皮肤溃疡患者48例随机分为2组,试验组外用朱红膏,对照组使用不含汞的龙珠软膏,于用药前及用药后2周、4周、6周,停药后2周、6周测其血汞及尿汞浓度。结果:血汞、尿汞浓度有随时间变化的趋势;时间因素的作用因分组的不同而不同;药物因素能升高患者血尿汞浓度,停药后浓度明显下降。结论:朱红膏外用于溃疡面积小于60 cm^2慢性皮肤溃疡患者6周,血尿汞随用药时间的延长有不同类型的波动形式,但其值仍在安全范围之内。Objective： To explore the absorption and excretion of Hg ions in human body. Methods： All 48 pa- tients with chronic skin ulcer were randomized into two groups, the experiment group accepted ZhuHong ointment for external use, and the control group used LongZhu cream which didn＇t contain mercury, The mercury concentra- tions in the blood and serum were detected before the medication, in two, four and six weeks after the medication, and in two and six weeks after stopping the medication. Results： The concentrations of blood mercury and urinary mercury changed as the time went by; the functions of time factor were different as the grouping was different; the factor of medicine could raise blood and urinary mercury concentrations between both groups, the concentrations decreased after stopping the medicine. Conclusion： When ZhuHong ointment was used to treat the ulcer of less than 60 cm^2 of the patients with chronic skin ulcer for six weeks, serum and urinary mercury show different waves as the medication time extends, but its value is still within safe limits.

关 键 词：慢性皮肤溃疡 血汞 尿汞 朱红膏 安全性 

分 类 号：R249[医药卫生—中医临床基础]