Non-coding Transcripts from Enhancers:New Insights into Enhancer Activity and Gene Expression Regulation  

作　　者：Hongjun Chen Guangshi Du Xu Song Ling Li 

机构地区：[1]Center for Functional Genomics and Bioinformatics,Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education,College of Life Science,Sichuan University [2]State Key Laboratory of Biotherapy,West China Hospital,Sichuan University

出　　处：《Genomics, Proteomics & Bioinformatics》2017年第3期201-207,共7页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Key Research and Development Project(Grant No.2017YFA0504300);the National Basic Research Program of China(973 Program;Grant No.2011CB504203);the National Natural Science Foundation of China(Grant Nos.81490752,31671347,31000579,31371325,and 30971634);the Doctoral Programs Foundation of the Ministry of Education,China(Grant No.20130181130010);the Research Foundation of Sichuan University for Excellent Youth Scholars(Grant No.2015SCU04A23)

摘　　要：Long non-coding RNAs （lncRNAs） have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs （eRNAs）. The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.Long non-coding RNAs （lncRNAs） have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs （eRNAs）. The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.

关 键 词：LncRNA Enhancer transcriptioneRNA Enhancer activity Gene expression 

分 类 号：Q78[生物学—分子生物学]