12周不同强度运动干预对大鼠心肺耐力的改善效果  

Effects of 12-week Exercise with Different Intensity on Improving Cardiorespiratory Fitness in Rats

作　　者：许杰[1,2] 谢敏豪[3] 严翊[2] 林家仕[4] 曹友祥 沈文清[2] 

机构地区：[1]成都大学,成都610106 [2]北京体育大学 [3]国家体育总局运动医学研究所 [4]集美大学

出　　处：《中国运动医学杂志》2017年第6期479-485,共7页Chinese Journal of Sports Medicine

基　　金：国家"十二五"科技支撑计划课题(2012BAK21B02);国家自然科学基金(31401017);教育部优秀博士论文课题(V200801)

摘　　要：目的:探究12周不同强度的运动干预对心肺耐力的提升效果,为改善心肺耐力的有效运动负荷评价提供理论支持。方法:40只雄性Wistar大鼠随机分为安静组、小强度组(50%VO2max)、中强度组(65%VO2max)、大强度组(80%VO2max),每组10只。安静组不运动,运动组适应性训练3天后测试最大摄氧量,之后每隔两周测试1次。运动组大鼠每天训练1h,每周5天。12周运动干预后,进行超声心动测试,测试各组大鼠心脏形态学及功能学指标。结果:(1)经过12周训练后,小强度组和大强度组大鼠体重显著低于安静组(P<0.05,P<0.01)。(2)12周运动干预后,3个运动组大鼠VO2max都显著高于安静组(P<0.01)。中强度组和大强度组VO2max提升效果较快,分别在第8周末和第6周末达到峰值。而小强度组在第10周末明显提升,并于12周末达到峰值。(3)大强度组左室收缩末内径显著低于小强度组(P<0.05),而射血分数和左室短轴缩短率则显著高于小强度组(P<0.05)。结论:(1)不同强度的运动都可以改善大鼠的心肺耐力,但相比中强度和大强度运动,小强度运动对心肺耐力的改善所需的运动干预时间更长。(2)只有大强度运动可以改善心脏泵血功能。Objective To explore the effectiveness of 12-week exercises with different intensities on cardiorespiratory fitness（CRF）of rats,so as to provide theoretical evidences for evaluating effective exercise loads. Methods Forty male Wistar rats were randomly divided into a low intensity group（50%VO2max）,a moderate intensity group（65%VO2max）,a high intensity group（80%VO2max）and a sedentary group,each of 10. All rats were measured the VO2 maxafter three-day adaptive training,then they were repeated the VO2 maxtest every two weeks on the non-training days and the load of the next two weeks wasadjusted according to the test result. The treadmill speed was controlled to maintain the specific exercise intensity of each group in the training period. The rats in the exercise groups were trained 5days per week and 60 minutes per day. After 12 weeks of exercise intervention,the ultrasonic cardio-gram tests were conducted. Results After 12 weeks of exercise,compared with the sedentary group,theaverage weight of the low and high intensity groups decreased significantly（P〈0.05,P〈0.01）. After the12-week exercise intervention,the average VO2 maxof the three exercise groups were significantly higher than the sedentary group（P〈0.01）. The average CRF of the moderate and high intensity group improved faster,with their peak value at the 6^thand 8^thweek respectively. However,in the low intensitygroup significant improvement in the average CRF was observed from the 10 ^thweek,with the peak value appearing at the 12^ thweek. The average left ventricular internal dimension systole of the high intensity group was lower than the low intensity group（P〈0.05）,while the ejection fraction and left ventricular shortening fraction increased significantly（P〈0.05）. Conclusions Exercises with different intensitycan improve the CRF. However,compared with moderate and high intensity exercise,it requires longertime to improve CRF with low intensity exercise. Only exercise with 80%VO2maxcan significantly improve the

关 键 词：心肺耐力 运动干预 强度 

分 类 号：R87[医药卫生—运动医学]