类弹性蛋白-蚕丝纤维复合材料的制备及性能研究  

Fabrication and property study of elastin-like polypeptide and silk complex scaffold

作　　者：陈卓玥[1,2] 魏琪[2] 王晋荣[1] 龙开平[1] 李红民[2] 

机构地区：[1]西京学院护理系,西安710123 [2]西北大学生命科学学院,西安710069

出　　处：《功能材料》2017年第6期6097-6103,6108,共8页Journal of Functional Materials

基　　金：陕西省教育厅专项科研计划资助项目(16JK2245);西京学院科研基金资助项目(XJ150130)

摘　　要：采用热交联、京尼平交联、原花青素交联和戊二醛/聚乙二醇交联4种方法制备类弹性蛋白-蚕丝纤维多孔支架材料。利用扫描电镜、傅立叶变换红外光谱和力学性能测试研究了交联类弹性蛋白-蚕丝纤维多孔材料的内部形态和结构。通过细胞毒性实验分析了不同方法交联类弹性蛋白-蚕丝纤维多孔材料的细胞相容性。结果表明,热交联和京尼平交联能制备出的类弹性蛋白-蚕丝纤维多孔支架材料具有较高和较稳定的力学性能,且具有良好的细胞相容性。Silk microfibers and Elastin-like polypeptide（ELP）were treated with four methods,（1）Dehydrothermal treatment（DHT）;（2）mixing with genipin;（3）mixing with proanthocyanidin（PA）;（4）mixing with PEG and glutaraldehyde（GA）.The resulting materials were characterized by scanning electron microscope（SEM）,Fourier transform infrared spectroscopy（FT-IR）and mechanical properties.The fiber reinforcement（SilkELP-DHT,Silk-ELP-Genipin and Silk-ELP-PEG-GA）resulted in the development of more mechanically robust constructs compared to silk alone.Meanwhile,the Silk-ELP-DHT and Silk-ELP-Genipin composite scaffolds show higher and more stable mechanical properties and better cytocompatibility.

关 键 词：类弹性蛋白 蚕丝纤维 多孔支架 性能 细胞相容性 

分 类 号：O629.73[理学—有机化学]