电感耦合等离子体发射光谱法测定右旋糖酐铁重金属元素中的电离干扰及抑制方法  

Ionization interference and its suppressing in determination of heavy metal elements in iron dextran by inductively coupled plasma optical emission spectrometry

作　　者：马超[1,2] 米楠[1,2] 房思萌[1,2] 臧可昕[1,2] 苏慕君[1,2] 

机构地区：[1]天津药物研究院制剂中心,天津300193 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《药物评价研究》2017年第4期506-512,共7页Drug Evaluation Research

摘　　要：目的建立用电感耦合等离子体发射光谱法(ICP-OES)测定右旋糖酐铁中铅、镉、砷、汞、钴、钒、硒、钼8种重金属元素的分析方法。方法通过检测波长考察,仪器参数优化,校正光谱干扰,验证电离干扰并考察抑制方法,测定8种重金属元素的量。结果抑制电离干扰,待测元素回收率提高5%~10%,方法准确度良好,加样回收率在95.7%~101.1%,方法精密度良好(RSD<3.6%,n=6)。各待测元素线性关系良好,相关系数均大于0.999,检出限为0.15~8.09 ng/m L,定量限为0.46~24.26 ng/m L。结论方法准确度高、灵敏度高、迅速可靠,可用于右旋糖酐铁中8种重金属元素的测定。Objective To establish a method for the determination of eight heavy metal elements ofPb,Cd,As,Hg,Co,V,Se,Mo in iron dextran by inductively coupled plasma optical emission spectrometry （ICP-OES）.Method Through selection of detection wavelengths,optimization of instrument parameters,correction of spectral interference,verification of ionization interference and investigation of suppression methods,the eight heavy metal elements were analyzed by ICP-OES.Results The recovery rate of the detected elements increased 5% to 10% by suppression of ionization interference.The accuracy of the method was good.The spiked recovery rates of the detected elements were from 95.7% to 101.1%.The precision of the method were good （RSD 〈 3.6%,n =6）.The linearities of the detected elements were good,and the correlation coefficients were all greater than 0.999.The detection limits were from 0.15 to 8.09 ng/mL.The quantization limits were from 0.46 to 24.26 ng/mL.Conclusion The method was accurate,sensitivity,rapid and reliable,which can be applied to the determination of contents of eight heavy metal elements in iron dextran.

关 键 词：电感耦合等离子体发射光谱法(ICP-OES) 电离干扰 右旋糖酐铁 

分 类 号：R917[医药卫生—药物分析学]