精酮合剂对小鼠的抗疲劳作用  

Anti-fatigue effect of L-arginine-α-ketoglutarate on mice

作　　者：蒋敏[1] 李琪倩 李恒[1] 许正宏[1,2] 史劲松[1] 

机构地区：[1]江南大学药学院制药工程实验室,江苏无锡214000 [2]江南大学生工学院,江苏无锡214000

出　　处：《生物资源》2017年第3期181-184,共4页Biotic Resources

摘　　要：通过观察小鼠负重力竭游泳时间探讨精氨酸-酮戊二酸盐(精酮合剂,AAKG)对小鼠的抗疲劳作用,分别测定小鼠游泳前后血清尿素含量、肝糖原含量、全血乳酸含量等指标以探讨AAKG抗疲劳机制。结果表明,经AAKG处理过的小鼠负重游泳时间(4.71±1.36min)比对照组小鼠(3.01±0.46min)明显延长(P<0.05),AAKG组小鼠血清尿素氮含量(177.94±17.7mg/L)明显低于对照组(202.38±8.95mg/L)(P<0.05),AAKG组小鼠乳酸曲线下面积(85.88±9.74mmol/L)也显著低于对照组(112.82±17.10mmol/L)(P<0.05),而AAKG组小鼠肝糖原含量(11.95±0.35mg/g)显著性高于对照组小鼠(8.42±0.97mg/g)(P<0.05)。本实验结果表明AAKG具有较好的抗疲劳作用,推测与其能够提高小鼠代谢能力和增强应激能力有关。The anti-fatigue effect of L-arginine-α-ketoglutarate（AAKG）was studied through weight loading swimming test on mice.Compared with control group（3.01±0.46min）,the swimming time of AAKG group was significantly increased（4.71±1.36 min）（P0.05）.Meanwhile,the production of serum urea（202.38±8.95mg/L for control group and 177.94±17.7mg/L for AAKG group）as well as the area under curve of serum lactic acid（112.82±17.10mmol/L for control group and 85.88±9.74mmol/L for AAKG group）were decreased while the content of glycogen（8.42±0.97mg/g for control group and 11.95±0.35mg/L for AAKG group）was increased significantly（P0.05）.The anti-fatigue effect of AAKG was obviously observed in mice,which might be related to the enhanced metabolic capacity and stress ability.

关 键 词：精酮合剂 抗疲劳 小鼠 

分 类 号：R285.5[医药卫生—中药学]