光催化烯烃加成/环化合成含氟异喹啉-1,3-二酮  

Synthesis of Fluorinated Isoquinoline-1,3-Dione via Light-Catalysis Addition and Cyclization of Alkenes

作　　者：张倩[1] 王琼[1] 邓佑林[1] 王硕文[1] 袁莉[1] 吴伊婷 唐石[1] 

机构地区：[1]吉首大学化学化工学院,湖南吉首416000

出　　处：《吉首大学学报（自然科学版）》2017年第3期69-75,共7页Journal of Jishou University(Natural Sciences Edition)

基　　金：国家自然科学基金资助项目(21462017);吉首大学大学生研究性学习和创新性实验计划项目(52);吉首大学校级科研项目(15JDY001)

摘　　要：发展了一种光催化活泼烯烃加成/环化合成含氟异喹啉-1,3-二酮的反应.在可见光催化下,多种N-烷基-N-甲基丙烯酰基苯甲酰胺衍生物与全氟碘代丁烷、溴二氟乙酸乙酯发生自由基串联加成环化反应,以67%~80%的产率合成了一系列具有潜在生理活性的含氟取代异喹啉-1,3-二酮衍生物.这为具有潜在药用价值的氟取代异喹啉-1,3-二酮的合成提供了一条绿色、高效、条件温和的途径.A synthesis of fluorinated isoquinoline-1,3-diones via light catalyzing activated alkenes addition reaction was developed.Through light catalysis,various N-alkyl-N-methacryloylbenamides derivatives underwent radical cascade addition cyclization reaction with perfluorobutyliodide and ethyl bromodifluoroacetate.A series of fluorinated isoquinoline-1,3-diones derivatives with potential physiological activity was compounded in 67%~80% yields.This study provides a green efficient approach to afford fluorinated isoquinoline-1,3-dione under mild conditions.

关 键 词：光催化 C—H环化 自由基 含氟异喹啉-1 3-二酮 

分 类 号：O621.3[理学—有机化学]