高压氧治疗狼疮性脑病疗效及对血清C反应蛋白及肾功能的影响  

Effect of hyperbaric oxygen therapy on lupus encephalopathy and its influence on serum CRP and renal function

作　　者：刘晓霞[1] 

机构地区：[1]温州市中医院康复科,浙江省温州325000

出　　处：《中国基层医药》2017年第15期2250-2253,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省温州市科技计划项目（Y20130065）

摘　　要：目的 探讨高压氧治疗狼疮性脑病疗效及对血清C反应蛋白（CRP）及肾功能的影响.方法 选取100例狼疮性脑病患者为研究对象,按照随机数字表法分为观察组和对照组,对照组给予常规措施治疗,观察组在对照组治疗措施基础上给予高压氧治疗,比较两组治疗效果及治疗前后CRP水平变化及肾功能指标改善情况.结果 观察组的总有效率（96.00%）高于对照组（68.00%）（χ^2=13.279,P=0.000）.观察组治疗后3 d、5 d、7 d时CRP水平[（17.53±1.58）μg/mL、（14.59±1.52）μg/mL、（9.39±1.01）μg/mL]明显低于对照组[（20.48±1.78）μg/mL、（18.49±1.32）μg/mL、（13.24±1.13）μg/mL],差异均有统计学意义（均P〈0.05）.观察组治疗后血尿素氮（BUN）、血清肌酐（SCr）明显优于对照组,差异均有统计学意义（t=12.069、15.203,P=0.000、0.000）.结论 高压氧治疗狼疮性脑病的疗效显著,改善患者症状,促进CRP水平恢复,缓解肾功能指标,临床意义重大.Objective To observe the effect of hyperbaric oxygen therapy on lupus encephalopathy and its influence on serum CRP and renal function.Methods 100 patients with lupus encephalopathy were selected and they were randomly divided into observation group and control group according to the digital table.The control group was treated with routine therapy.The observation group was given hyperbaric oxygen therapy and routine therapy.The therapeutic effects of two groups were compared and the changes of CRP level and the improvement of renal function before and after treatment were analyzed.Results The total effective rate of the observation group was 96.00%,which was significantly higher than 68.00% of the control group （χ^2=13.279,P=0.000）.After treatment for 3d,5d,7d,the CRP levels of the observation group were （17.53±1.58）μg/mL,（14.59±1.52）μg/mL,（9.39±1.01）μg/mL,respectively,which were significantly lower than those of the control group[（20.48±1.78）μg/mL,（18.49±1.32）μg/mL,（13.24±1.13）μg/mL],the differences were statistically significant （all P〈0.05）.After treatment,the blood urea nitrogen （BUN）,serum creatinine （SCr） of the observation group were significantly better than those of the control group,the differences were statistically significant （t=12.069,15.203,P=0.000,0.000）.Conclusion Hyperbaric oxygen exerts significant effect in treatment of lupus encephalopathy can improve symptoms,promote the recovery of CRP levels,relieve renal function,and has clinical significance.

关 键 词：红斑狼疮 系统性 脑损伤 慢性 高压氧 C反应蛋白质 

分 类 号：R593.241[医药卫生—内科学] R747.9[医药卫生—临床医学]