高龄男性血清N端骨钙素的独立相关因素探讨  

Related factors to serum osteocalcin level in elderly men

作　　者：夏清[1] 边平达[1] 应奇峰[1] 李秀央[2] 寿张轩[1] 陈锦平[1] 

机构地区：[1]浙江省人民医院骨质疏松诊疗中心,杭州310024 [2]浙江大学流行病与卫生统计学系

出　　处：《浙江医学》2017年第12期967-970,共4页Zhejiang Medical Journal

基　　金：浙江省医药卫生平台重点资助计划项目(2016ZD A002);浙江省人民医院优秀青年人员科研启动基金(zry2015C002)

摘　　要：目的探讨高龄男性血清骨钙素的独立相关因素。方法对1 429例高龄男性进行一般情况调查,检测骨转换标志物、血生化和性激素等指标,采用多元回归分析方法筛选高龄男性血清骨钙素的独立相关因素。结果高龄男性骨钙素的独立相关因素有甲状旁腺素(β=0.074,P=0.000)、肌酐(β=0.049,P=0.000)、癌症(β=2.431,P=0.000)、BMI(β=-0.158,P=0.016)、血钠(β=0.239,P=0.003)、雌二醇(β=-0.036,P=0.033)和2型糖尿病(β=-1.044,P=0.036)。结论积极防治癌症和肾功能不全,降低血清甲状旁腺素和血钠水平,维持合理的BMI和雌二醇水平,可能是降低高龄男性血清骨钙素水平的重要方法。Objective To investigate the related factors to serum osteocalcin level in elderly men. Methods A cross-sectional survey was conducted comprising a sample of 1 429 men aged 80 and over. Serum osteocalcin, parathyroid hormone, 25-hydroxyvitamin D and sex steroids were measured. The related factors to serum osteocalci level were analyzed with univariate and multivariate regression analyses. Results Multivariate analysis showed that parathyroid hormone（β=0.074, P =0.000）, creatinine（β=0.049, P =0.000）, cancer（β=2.431, P =0.000）,body mass index（β=-0.158, P =0.016）,serum sodium（β=0.239, P =0.003）, estradiol（β=-0.036, P =0.033）, and type 2 diabetes mellitus（β=-1.044,P =0.036） were independent associated factors of serum osteocalcin level in elderly men. Conclusion The probable ways to decrease osteocalcin in men aged 80 and over are to prevent and cure cancer and chronic renal failure,to decrease the concentration of serum parathyroid hormone and serum sodium, and keep a proper body mass index and the concentration of serum estradiol.

关 键 词：骨转换标志物 骨钙素 甲状旁腺素 高龄男性 

分 类 号：R580[医药卫生—内分泌]