420例原发性高血压患者血压昼夜节律性分析与中医证素的相关性研究  

Correlation between blood pressure circadian rhythms and TCM syndrome elements in 420 patients with essential hypertension

作　　者：梁君昭 董秋芬 马丽君[3] 苏建[3] 姜浩[3] 高琪[3] 刘畅[3] 

机构地区：[1]陕西省西安市中医医院科教科,陕西西安710021 [2]湖北省中医医院ICU科,湖北武汉710021 [3]陕西中医药大学

出　　处：《河北中医》2017年第6期825-829,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：陕西省社会发展科技攻关项目(2015年度)(编号:2015SF233)

摘　　要：目的探讨原发性高血压患者血压昼夜节律性与中医病性证素实性因素的相关性。方法按照流行病学调查研究的要求,制订原发性高血压临床调查表,收集420例原发性高血压患者的一般资料、监测并记录24 h动态血压,探讨各类型血压昼夜节律性与中医病性证素实性因素的相关性。结果本组420例患者血压昼夜节律性类型频数分S布为非杓型>杓型>超杓型>反杓型,血压昼夜节律性异常者占大多数,以非杓型最多见,与其他类型比较差异有统计学意义(P<0.05)。本组420例患者血压昼夜节律性类型与患者年龄之间比较差异无统计学意义(P>0.05),说明原发性高血压患者血压昼夜节律性与年龄无关。本组420例患者病性证素实性因素分布:阳亢>痰湿>血瘀>气滞>其他,以阳亢证素、痰湿证素最多见,二者之间比较差异无统计学意义(P>0.05),分别与其他各实性证素比较差异有统计学意义(P<0.05)。痰湿证素与非杓型和反杓型血压昼夜节律因素呈正相关;阳亢证素与非杓型血压昼夜节律性呈负相关,与超杓型血压昼夜节律性呈正相关。结论原发性高血压患者所涉及的主要病性证素实性因素为阳亢、痰湿;原发性高血压患者中血压昼夜节律性异常者以非杓型血压昼夜节律性类型为主;原发性高血压阳亢、痰湿证素与血压昼夜节律性存在确切相关性。Objective To explore the correlation between blood pressure circadian rhythms and traditional Chinese medicine（ TCM） syndrome elements in 420 patients with essential hypertension. Methods According to the requirements of epidemiological investigation,a clinical questionnaire of essential hypertension was formulated for collecting the general data of 420 patients with essential hypertension,and 24 hours ambulatory blood pressure were monitored and recorded to explore the correlation between all kinds of blood pressure circadian rhythms and TCM syndrome elements. Results The frequency distribution of blood pressure circadian rhythm type in 420 cases from more to less,followed by non-dipper type,dipper type,anti-dipper type,over-dipper type. Abnormal blood pressure circadian rhythm accounted for the majority,and most of which are non-dipper type with statistical differences incomparison with other types（ P〈0. 05）. There was no statistical difference between blood pressure circadian rhythm and age（ P〈0. 05）,which showed blood pressure circadian rhythm had nothing to do with age. The solid syndrome elements of TCM in 420 patients with essential hypertension from more to less,followed by yang-hyperactivity,phlegm-dampness,blood-stasis,qi-stagnation and the others,among them,the syndrome elements of yang-hyperactivity and phlegm-dampness were the most common,there was no statistical difference between them yang-hyperactivity and phlegm-dampness（ P〈0. 05）,but there were statistical differences between the yang-hyperactivity and the solidsyndrome elements,and as well as the phlegm-dampness（ P〈0. 05）. The phlegm-dampness had positive correlation with non-dipper type and anti-dipper type. The yang-hyperactivity had negative correlation with non-dipper type,and had positive correlation with over-dipper type. Conclusion The main solid syndrome elements involved in essential hypertension patients are yang-hyperactivity and phlegm-dampness. The blood pressure circadian rhythm in essential hypertensio

关 键 词：高血压 血压 昼夜节律 证候 

分 类 号：R544.1[医药卫生—心血管疾病] R2-03[医药卫生—内科学]