肠道菌群失衡诱发肠易激综合征的机制  

The mechanisms of irritable bowel syndrome induced by gut microbiota dysbiosis

作　　者：欧枢 贾玉杰[2] OU Shu JIA Yujie(Public Health,College, Dalian Medical University, Dalian, Liaoning 116044, China)

机构地区：[1]大连医科大学公共卫生学院,辽宁大连116044 [2]大连医科大学基础医学院病理生理学教研室,辽宁大连116044

出　　处：《中国微生态学杂志》2017年第6期742-744,F0003,共4页Chinese Journal of Microecology

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种常见的功能性胃肠道疾病,严重地威胁着人类的健康与生存质量。最近的研究发现IBS的发病机制是复杂多样的,尽管其确切的发病原因尚不完全清楚,但有证据显示IBS可能与肠道菌群失衡有关。本文就有关肠道菌群的功能、IBS患者肠道菌群的特点、肠道菌群失衡导致IBS发病的可能机制的研究进展作一综述,旨在为IBS的早期诊断与有效治疗提供有价值的理论依据。Irritable bowel syndrome （IBS） is one of the most common functional bowel diseases, which severely threats human health and quality of life. Recent research had found that the pathogenesis of IBS was complicated. Although the definite etiology and pathogenesis are not fully clear up so far, many evidences have demonstrated that IBS may be closely associated with the gut microbiota dysbiosis. We will discuss the composition of normal intestinal flora, characteristics of intestinal flora in the patients of IBS and possible mechanism of IBS induced by gut microbiota dysbiosis. The purpose is to supply the valuable theoretical basis for early diagnosis and effective treatment in IBS.

关 键 词：肠易激综合征 肠道菌群失衡 机制 

分 类 号：R117[医药卫生—公共卫生与预防医学] R363.2