肾素-血管紧张素系统两轴及其平衡与急性胰腺炎关系的研究进展  

Research progress of the relationship between the balance of the two axes in rennin-angiotensin system and the acute pancreatitis

作　　者：裴茂炜[1] 胡铭荣[1] 

机构地区：[1]杭州师范大学附属医院普外科,浙江杭州310015

出　　处：《中国急救医学》2017年第6期564-567,共4页Chinese Journal of Critical Care Medicine

摘　　要：肾素-血管紧张素系统（RAS）是重要的激素调节系统.研究发现,RAS参与了急性胰腺炎（AP）的发生发展.目前认为,RAS主要由血管紧张素转换酶（ACE）-血管紧张素（AngⅡ）及其受体（AT1R等）（ACE-AngⅡ-AT1）经典轴和血管紧张素转换酶2（ACE2）-血管紧张素（1-7）[Ang（1-7）]-及其受体Mas [ACE2-Ang（1-7）-Mas]新轴组成.ACE-AngⅡ-AT1经典轴促进胰腺微循环障碍,加剧炎症反应及氧化应激,进而加重AP的病情;而ACE2-Ang（1-7）-Mas新轴能拮抗ACE-AngⅡ-AT1经典轴,对AP具有潜在的保护作用.两轴的调节失衡,可能决定AP的预后.调控并维持两轴的平衡,或有助于决策AP的治疗方案.本文拟对RAS两条轴与AP的关系做一综述.The rennin-angiotensin system（RAS）is an important hormonal regulation system.Studies have shown that activation of RAS is closely related to the pathophysiology of acute pancreatitis（AP）.It is thought that the RAS is composed of the classical ACE-AngⅡ-AT1 axis and the new ACE2-Ang（1-7）-Mas axis.The ACE-AngⅡ-AT1 axis will exacerbate the aggravation of AP through pancreatic microcirculation disturbances, inflammation and oxidative stress.However, recent studies indicated that the new ACE2-Ang（1-7）-Mas axis may antagonize the function of the classical axis which will decrease the progress of AP.The imbalance of the two axes may determine the prognosis of AP.Regulation and maintenance the balance of the two axes may contribute to the treatment.This review will focus on the relationship between the two axes and the acute pancreatitis.

关 键 词：急性胰腺炎(AP) 肾素-血管紧张素系统(RAS) 综述 轴 

分 类 号：R544.1[医药卫生—心血管疾病]