马齿苋黄酮抗衰老作用研究（英文）  

Anti-aging Effects of Flavonoids from Portulaca oleracea L.

作　　者：尹爱武[1] 高鹏飞 党丽敏[1] 

机构地区：[1]湖南工程学院化学化工学院,湘潭411104 [2]大理大学药学院,大理671000

出　　处：《天然产物研究与开发》2017年第6期988-993,共6页Natural Product Research and Development

基　　金：co-financed by Natural Science Foundation of China(81260676);New Dr.Fund of Hunan Institute of Engineering(16RC019)

摘　　要：本文研究马齿苋黄酮的抗衰老作用。给药(FPO)6周后测定血清、肝和脑组织谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)的活力,丙二醛(MDA)的含量及小鼠胸腺和脾脏指数。水迷宫试验与跳台试验测定马齿苋黄酮对衰老小鼠学习与记忆能力的影响。结果显示马齿苋黄酮能显著增加小鼠胸腺和脾脏指数,显著增强血清、肝和脑组织GSH-Px和SOD活力及显著减少其中MDA含量。马齿苋黄酮能显著减少水迷宫试验中小鼠的逃避潜伏期及跳台试验中反应时间与错误次数;显著增加水迷宫试验中小鼠的穿越次数与跳台试验中的记忆潜伏期。马齿苋黄酮有显著的抗衰老作用。This study was performed to investigate the anti-aging effects of flavonoids from Portulaca oleracea L. （FPO）. After giving the drug （FPO） for 6 weeks, the effects of FPO on the activities of GSH-Px （glutathione peroxidase）, SOD （ superoxide dismutase） and the content of MDA （malondialdehyde） in serum, brain and liver tissue were assayed using commercial monitoring kits, and the thymus index and spleen index were also measured. The effects of FPO on learning and memory ability was assessed by Morris water maze and step down test. The results showed that the activities of GSH- Px and SOD in serum, brain and liver tissue were increased significantly by FPO, while the content of MDA was de- creased significantly. The thymus index and spleen index were also markedly increased. FPO markedly decreased the es- cape latency and increased the escape times in water maze test. In step down test, reaction time of learning, as well as er- ror frequency in learning and memory, was markedly decreased by FPO, whereas the latency of memory was markedly in- creased. These results indicated that FPO had a significant anti-aging effect.

关 键 词：马齿苋 水迷宫 超氧化物歧化酶 丙二醛 谷胱甘肽过氧化物酶 

分 类 号：R965[医药卫生—药理学]