妇产科139401例患者梅毒血清学抗体检测结果统计分析  

Statistical Analysis of Syphilis Antibody Detection Results in 139 401 Obstetrics and Gynecology Patients

作　　者：李文娟[1] 张月香[1] 米东[1] 祁珮[1] 张双革[1] 

机构地区：[1]天津市中心妇产科医院检验科,天津300100

出　　处：《中国皮肤性病学杂志》2017年第7期760-763,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的了解妇产科患者梅毒感染情况,为女性梅毒的防治尤其是孕产妇梅毒防治工作提供参考依据。方法选取2011-2015年天津市中心妇产科医院就诊的女性患者139 401例作为研究对象(不含新生儿),用酶联免疫吸附试验(ELISA)进行血清梅毒抗体筛查,阳性者用梅毒螺旋体抗体明胶凝集试验(TPPA)进行确证,两者均为阳性者认为梅毒血清学阳性,通过快速血浆反应素试验(RPR)检测其效价。对不同年度、不同年龄段和科室梅毒检测结果进行统计分析。结果共检出阳性患者1 197例,阳性率0.86%,阳性患者中TPPA阳性RPR效价阴性者占53.13%,RPR高滴度患者主要为21~30岁年龄组。妇瘤科检出率最高,产科最低。≤20岁年龄组检出率最高。近五年本院梅毒阳性检出率依次为0.80%,0.87%,0.82%,0.80%和1.00%,2011-2014年梅毒阳性检出率基本相近,2015年明显升高,与前4年相比差异有统计学意义(χ~2=8.745,P<0.01)。结论梅毒血清学阳性患者各科室均有检出,且有年轻化趋势,2015年产科梅毒检出率显著升高,加强年轻女性特别是孕妇梅毒筛查有利于降低梅毒垂直传播风险,进而控制梅毒传播。Objective To investigate the information of patients with syphilis infection in our obstetrics and gynecology hospital, and further provide a reference for syphilis prevention especially for pregnacy patients. Methods A total of 139401 women patients in our hospital from 2011 to 2015 were participate in this research, syphilis antibody was screened preliminary by Enzyme-linked immunosorbent assay（ELISA）, then the method of treponema pallidum antibody gelatin agglutination test（TPPA）was used to confirm it. If the result is positive the syphilis patients will be diagnose exactly, and further the papid plasma reagent（RPR）test was used to determine the titer of syphilis antibody. Detection results were analyzed in different groups for different years, age and departments. Results One thousand one hundred and ninety-seven cases were diagnosed as syphilis patients with 0.86% positive rate.In syphilis patients with TPPA positive and RPR negative accounted for 53.13%, high titers RPR patients mainly for 21-30 years old age group. The positive rate of syphilis in gynecologic oncology department is highest, in obstetric department is lowest, and the positive rate in 2～20 years old is highest. In nearly five years, positive rate of syphilis was 0.80%, 0.87%, 0.82%, 0.80%and 1.00% respectively, from 2011 to 2014, the positive rate of syphilis in our hospital was basically stable, but it is increased significantly in 2015, the difference was significant compared with the first four years（χ2= 8.745, P〈 0.01）. Conclusion The syphilis distribute in all clinical department,and the age of syphilis patients showed a younger tendency, cases in the obstetrics department statistically increased in 2015. Syphilis screening strengthened in young women especially pregnant can reduce the risk of vertical transmission of syphilis, and control it＇s spread.

关 键 词：于降低梅毒垂直传播风险 进而控制梅毒传播. 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]