反应性穿通性胶原病3例及文献复习  

Three Cases of Reactive Perforating Collagenosis and Literature Review

作　　者：吕静[1] 肖沙[1] 郝进[1] 赵鹏[1] 闫衡[1] 刁庆春[1] 闫国富[1] 刘娟娟[1] 

机构地区：[1]重庆市第一人民医院皮肤科,重庆400011

出　　处：《中国皮肤性病学杂志》2017年第7期770-773,共4页The Chinese Journal of Dermatovenereology

基　　金：重庆市科委技术研发平台专项"重庆市皮肤病临床医学研究中心"建设项目(cstc2015yfpt-gcjsyjzx120014)

摘　　要：3例患者均为中老年男性,皮疹多泛发全身或仅累及双下肢,合并2型糖尿病、乙肝小三阳、高血压、高血脂、肾功能衰竭等疾病。临床均表现为丘疹、结节,中央可见脐状凹陷,内填充角栓。组织病理检查示表皮呈杯形下陷,下方为坏死变性的胶原和白细胞碎屑,坏死胶原从表皮穿出。诊断:反应性穿通性胶原病。给予阿维A、沙利度胺、火把花根等药物或(和)抗生素软膏外用治疗后有效。Three cases of reactive perforating collagenosis were reported. The patients were middle-aged and elderly men,whose rashes were all over the body or on the both lower extremitities. At the time of presentation,there were numerous dome-shaped nodules, which had a central umbilication containing firm keratotic plugs.The three patients were associated with some systemic diseases, such as type 2 diabetes,hepatitis B,hypertensive disease,hyperlipemia,renal failure and so on. Histopathology showed a cup-shaped plug over degenerative collagen and leucocye patches in the epidermis,which was interlinked with dermis.The diagnosis was made as reactive perforating collagenosis. It was effective that oral use of retinoid and thalidomide.

关 键 词：胶原病 穿通性 反应性 文献复习 

分 类 号：R593.2[医药卫生—内科学]