SDF-1/CXCR4轴在结直肠癌发病中的研究进展  

Research Progress in the Preventing Colorectal Cancer through SDF-1/CXCR4 Axis

作　　者：李娟[1] 唐东昕[1] 杨柱[1] 龙奉玺[1] 罗莉[1] 王镜辉[1] 郭斌[1] 陈杰[1] 王倩[1] 

机构地区：[1]贵阳中医学院,贵州贵阳550002

出　　处：《贵阳中医学院学报》2017年第4期88-92,共5页Journal of Guiyang University of Chinese Medicine

基　　金：国家自然科学基金地区科学基金项目;项目名称:基于"治未病"理论探讨葛根散通过SDF-1/CXCR4轴干预结直肠癌肝转移的作用及机制;项目编号:81460697;贵州省研究生工作站计划(教育厅);项目名称:中医肿瘤学研究生工作站;项目编号:黔教研合JYSZ字[2014]018;贵州省科技支撑计划项目(社会发展攻关);项目名称:中医药对肺癌;大肠癌及癌性疼痛干预的应用基础及临床研究;项目编号:黔科合SY字[2014]3026号

摘　　要：结直肠癌(colorectal carcinoma,CRC)好发于直肠以及乙状结肠,故两者统称为大肠癌。本病发病机制中研究最多的是基质细胞衍生因子1(stromal cell-derived factor-1 SDF-1)及其特异性受体CXCR4(chemokine receptor 4),两者所构成的生物轴在结直肠癌的发生及病情进展中起着关键作用。故本文通过阐述SDF-1、CXCR4、以及两者组成的SDF-1/CXCR4轴的概念,其分别在大肠癌中的表达方面阐述本病的发病机制及通过干扰此轴治疗大肠癌进行归纳总结。Colorectal Cancer （Colorectal carcinoma, CRC） often occurs on the rectum and sigmoid colon, so they are collectively referred to as colorectal cancer. One of the pathogenesis of the disease is that Stromal cell derived factor 1 （stromal cell-derived factor-1 SDF - 1 ） and its specific receptor CXCR4 （chemokine receptor4） , and the composition of the biological axis plays a key role in the tumorigenesis and the development of the disease. Therefore, the paper was write to describe the concepts of SDF-1, CXCR4, and SDF-1/CXCR4 axis, and describe the pathogenesis of CRC and summarize the treatment of colorectal cancer by interfering with this axis.

关 键 词：SDF-1CXCR4 结直肠癌 防治 

分 类 号：R273[医药卫生—中西医结合]