地塞米松对未足月胎膜早破孕妇妊娠结局的影响  

Influence by dexamethasone on pregnancy outcome in pregnant women with preterm premature rupture of membranes

作　　者：林珏莹[1] 

机构地区：[1]揭阳市人民医院产科,522000

出　　处：《中国实用医药》2017年第17期121-123,共3页China Practical Medicine

摘　　要：目的探究地塞米松对未足月胎膜早破孕妇妊娠结局的影响。方法 70例未足月胎膜早破孕妇,随机分为对照组和观察组,每组35例。对照组孕妇未使用地塞米松,观察组孕妇实施地塞米松治疗。比较两组孕妇妊娠结局、新生儿预后情况、破膜至分娩时间及产程。结果观察组孕妇脐带脱垂、产后出血、剖宫产、死产及新生儿死亡发生率均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组新生儿Apgar评分为(8.06±3.44)分,对照组新生儿Apgar评分为(5.16±3.57)分,观察组新生儿Apgar评分高于对照组,差异具有统计学意义(t=3.461,P<0.05)。观察组孕妇破膜至分娩时间及产程均短于对照组,差异具有统计学意义(P<0.05)。结论地塞米松治疗未足月胎膜早破孕妇能有效缩短破膜至分娩时间及产程,提高产妇生产的安全性及新生儿的存活率,并能有效减少新生儿不良情况的发生,在临床应用中具有较高的推广价值。Objective To analyze curative effect by carboprost tromethamine injection combined with calcium gluconate in prevention of postpartum hemorrhage after cesarean section. Methods A total of 84 patients with postpartum hemorrhage after cesarean section were randomly divided into control group and observation group, With 42 cases in each group. The control group received oxytocin ＋ misoprostol for treatment, and the observation group received oxytocin ＋ carboprost tromethamine ＋ calcium gluconate for treatment. Curative effects were compared between the two groups. Results The control group had postpartum 15 min bleeding volume as （75.71 ± 11.26） ml, postpartum 2 h bleeding volume as （132.26 ± 12.41） ml, and postpartum 24 h bleeding volume as （287.16± 14.17） ml, which were all higher than （58.14 ± 10.37）, （95.49 ± 11.64） and （145.59±13.75） ml in the observation group, and their difference had statistical significance （P〈0.05）. The observation group had higher incidence of adverse reactions （14.29%） than the control group （9.52%）, while their difference had no statistical significance （P〉0.05）. Conclusion Combination of carboprost tromethamine and calcium gluconate can effective prevent postpartum hemorrhage after cesarean section, along with few adverse reactions and high safety. This method is worth widely clinical application.

关 键 词：地塞米松 未足月胎膜早破 妊娠结局 

分 类 号：R714.433[医药卫生—妇产科学]