应用美托洛尔治疗慢性阻塞性肺疾病对患者心肺功能及预后的影响  

Effect of Metoprolol on Cardiopulmonary Function and Prognosis of Patients with Chronic Obstructive Pulmonary Disease

作　　者：郭劼琳 张灿强[2] 何继宏[2] 张芳娣[2] 

机构地区：[1]惠州市惠城区慢性病防治站,广东惠州516001 [2]惠州市第三人民医院

出　　处：《湖北科技学院学报（医学版）》2017年第3期191-194,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的观察美托洛尔治疗慢性阻塞性肺疾病对患者心肺功能及预后的影响。方法选取105例慢性阻塞性肺疾病患者,随机分为观察组(n=53)和对照组(n=52),观察组在对照组常规治疗基础上应用美托洛尔,观察两组患者心肺功能临床指标、活动能力及恢复效果。结果两组患者治疗后心率、左心室舒张末期内经(LVD)、左室射血分数(LVEF)、肺动脉压、血氧饱和度、收缩压均有显著性变化(P<0.05),而一秒用力呼气量(FEV1)则与治疗前差异不显著(P>0.05);心率、LVEF及收缩压的变化方面观察组优于对照组(P<0.05)。治疗前及治疗1周两组六分钟步行距离比较差异不显著,治疗3个月及6个月,观察组结果优于对照组(P<0.05)。两组恢复情况与治疗前相比均有显著提高(P<0.05),治疗后观察组活动能力(MA)、疾病影响(DA)项目得分显著低于对照组(P<0.05)。观察组急性发作率、再住院率分别为18.87%、11.32%,对照组分别为48.08%、46.15%,两组比较具有统计学差异(P<0.05),两组死亡率、用药后不良反应发生率比较,不具有统计学差异(P>0.05)。结论应用美托洛尔治疗慢性阻塞性肺疾病效果较好,能有效改善患者心肺功能、活动能力及生活质量,值得临床借鉴。Objective To explore the effect of metoprolol on cardiopulmonary function and prognosis in patients with chronic obstructive pulmonary disease（ COPD）. Methods 105 patients with COPD were enrolled in our hospital,and were divided into the treatment group（ n = 53） and the control group（ n = 52）. The treatment group was treated with metoprolol on the basis of routine treatment of the control group. The heart and lung function,clinical indexes,activity ability and recovery effect were recorded in the two groups. Results The heart rate,LVD,LVEF,pulmonary artery pressure,blood oxygen saturation,systolic blood pressure in the two groups were significantly changed after treatment（ P〈 0. 05）,while FEV1 was no significant difference from that before treatment（ P 〉0. 05）; The changes of heart rate,LVEF and systolic blood pressure in treatment group were better than that in the control group after treatment（ P〈 0. 05）. There was no statistical difference in 6 min walking distance between the two groups before the treatment or 1 week after treatment. But the bove indicators were better in the treatment group compared with the control group 3 and 6 months after the treatment（ P〈 0. 05）.The recovery of the two groups was significantly higher than that before treatment（ P 〈0. 05）,the scores of MA and DA in the treatment group were significantly lower than that of the control group（ P〈 0. 05） after treatment. The acute attack rate and rehospitalization rate in the treatment group were 18. 87% and 11. 32% respectively,and 48. 08% and 46. 15% in the control group respectively. There was statistically significant difference between the two groups（ P 〈0. 05）. There was no statistical difference between the two groups in mortality and adverse drug reactions（ P 〉0. 05）. Conclusion Metoprolol can significantly improve heart function and life quality of patients with COPD,and it should be regarded as a clinical drug which can be applied to the treatment in chronic heart failure

关 键 词：慢性阻塞性肺疾病 美托洛尔 心肺功能 

分 类 号：R563[医药卫生—呼吸系统]