N-取代马来酰亚胺光敏感纳米粒子的制备及其药物可控释放性能研究  

Study on synthesis and control release of N-substituted maleimide photosensitive nanoparticle

作　　者：吴弟 余丽丽[2] 罗晓民[1] 

机构地区：[1]陕西科技大学轻工科学与工程学院,陕西西安710021 [2]西安医学院药学院,陕西西安710021

出　　处：《陕西科技大学学报》2017年第4期16-20,共5页Journal of Shaanxi University of Science & Technology

基　　金：陕西省教育厅产业化培育计划项目(16JF003)

摘　　要：以甲基丙烯酸甲酯(MMA)和呋喃保护的N-羟乙基马来酰亚胺的甲基丙烯酸酯(D)为单体,偶氮二异丁腈(AIBN)为引发剂,含有邻硝基苄基的邻硝基苯乙二醇二甲基丙烯酸甲酯(CL)为光敏感交联剂,通过微乳聚合的方法制备了一种新型光敏感纳米粒子.并以尼罗红(NR)作为模型分子,研究了纳米粒子对脂溶性药物的包载和释放性能.A novel type of photosensitive nanoparticles were prepared by a microemulsion polymerization process,using methyl methacrylate(MMA)and furan protected methacrylate Nhydroxyethyl maleimide(D)as monomers,2,2-azobisisobutyronitrile(AIBN)as initiator,O-nitrophenyl ethylene glycol dimethacrylate(CL)containing O-nitrobenzyl as photosensitive cross-linker.Package load capacity and the light controlled release ability of this nanoparticles for liposoluble drugs were studied using Nile red(NR)as the model molecules.

关 键 词：邻硝基苄基 N-取代马来酰亚胺 光敏感 微乳聚合 

分 类 号：O625.61[理学—有机化学]