MRI弥散加权成像评估肝癌伽玛刀疗效的临床研究  

Clinical study on the evaluation of gamma knife in the treatment of advanced liver cancer by MRI-diffusion-weighted imaging

作　　者：赵国礼[1] 杨学东[1] 张志良[1] 马戈[1] 洪伟[1] 万军平[1] 杨建辉[1] 

机构地区：[1]解放军第四一一医院,上海200081

出　　处：《海军医学杂志》2017年第3期242-243,247,共3页Journal of Navy Medicine

摘　　要：目的 MRI弥散加权成像评估肝癌伽玛刀治疗的疗效。方法 100例肝癌患者在伽玛刀治疗前1~2 d,伽玛刀治疗后7 d,治疗后1个月进行磁共振弥散加权成像检查,比较MRI在不同的b值下伽玛刀治疗肝癌前后的弥散系数(ADC)值的差别。结果选择不一样的b值,伽玛刀治疗前后病灶平均ADC值的差异有统计学意义(P<0.05),b值增大,平均ADC值也随着升高;伽玛刀治疗后各组病灶ADC的平均值较治疗前升高,治疗后30 d病灶ADC的平均值较治疗后7 d的平均值高。结论伽玛刀治疗后肝癌ADC值的变化是和肿瘤坏死密切相关的,ADC值可以用来评价伽玛刀治疗肝癌的疗效。Objective To evaluate the therapeutic effect of gamma knife on advanced liver cancer patients with MRI diffu-sion-weighted imaging （MRI-DWI）. Methods MRI-DWI detection was performed in 100 liver cancer patients 1-2 days before gamma knife therapy, 7 days and 30 days after gamma knife therapy. Then, comparisons were made between the dynamic changes of ADC val-ues before and after gamma knife therapy under different b-values. Results Under different b values, significant changes in the average ADC values of foci could be noted, before and after gamma knife therapy, and the average ADC values increased with the increase of the b value（P 〈 0. 05）. Following gamma knife therapy, the average ADC values of foci all increased as compared with those before thera-py. Thirty days after treatment, the average ADC values of foci were increased as compared with those 7 days after treatment. Conclusion ADC value changes after gamma knife therapy in the treatment of advanced liver cancer were closely related with tumor necrosis, and ADC values could be used for the assessment of the efficacy of gamma knife therapy.

关 键 词：MRI弥散加权成像 肝癌 伽玛刀 

分 类 号：R445[医药卫生—影像医学与核医学]