匹维溴铵联合氟哌噻吨美利曲辛治疗肠易激综合征的系统评价  

System Evaluation on the Efficacy of Pinaverium Bromide Combined with Flupentixol-melitracen in the Therapy of Irritable Bowel Syndrome:A Meta-analysis of Randomized Controlled Trials

作　　者：冉红梅[1] 潘涛[1] 何丹端 Ran Hongmei Pan Tao He Danduan.(Chengdu First People＇s Hospital, Chengdu 610041, China)

机构地区：[1]成都市第一人民医院,成都610041

出　　处：《成都医学院学报》2016年第4期446-451,共6页Journal of Chengdu Medical College

摘　　要：目的了解匹维溴铵联合氟哌噻吨美利曲辛与单用匹维溴铵治疗肠易激综合征(IBS)的疗效和安全性,为临床实践提供证据。方法检索Cochrane图书馆、Pubmed数据库、维普中刊数据库、万方数据库、中国生物医学文献数据库等,检索出匹维溴铵联合氟哌噻吨美利曲辛与单用匹维溴铵治疗IBS的研究,进行资料提取及方法学质量评价,并采用Revman5.3软件对总有效率、不良反应发生率、汉密尔顿焦虑及抑郁评分进行Meta分析。结果共检索出16个符合纳入标准的研究,包括1 688例患者进入本系统评价。14个试验的Meta分析提示,匹维溴铵联合氟哌噻吨美利曲辛治疗IBS与单用匹维溴铵比较,联合治疗总有效率优于单用匹维溴铵(P<0.000 01)。3个研究的汉密尔顿焦虑及抑郁评分的Meta分析提示,联合治疗组低于单用匹维溴铵组(P<0.000 01)。6个试验研究了不良反应发生率,联合治疗组高于单用匹维溴铵组(P=0.008)。结论匹维溴铵与氟哌噻吨美利曲辛联合治疗IBS的疗效优于单用匹维溴铵,且能改善精神情绪障碍,但还需进一步高质量、多中心的研究。Objective To evaluate the efficacy and safety of Pinaverium Bromide combined with Flupentixolmelitracen in the therapy of irritable bowel syndrome（IBS）and offer the reliable evidence for clinical practice.Methods The studies on Pinaverium Bromide combined with Flupentixol-melitracen in the therapy of IBS were collected from the Cochrane Library,PubMed,Chinese VIP database, WANFANG database and Chinese Biomedical Database.The collected data were assessed and extracted by two reviewers,and the meta-analysis was conducted to analyze the total effective rate,the incidence of adverse reactions,and the scores of Hamilton anxiety and depression scale with the help of the statistical software RevMan 5.3.Results 16 clinic trials involving 1 688 patients were included in the meta-analysis.The results of the meta-analysis indicated that Pinaverium Bromide combined with Flupentixol-melitracen was significantly better than Pinaverium Bromide in the total effective rate of14 clinic trials（P〈0.000 01）and the scores of Hamilton anxiety and depression scale of 3trials（P〈0.000 01）,but it was significantly higher in the incidence of adverse reactions（P=0.008）.Conclusion Pinaverium Bromide combined with Flupentixol-melitracen is more effective in the therapy of IBS than Pinaverium Bromide,and it can improve dysthymic disorder.However,more high quality trials are needed for further confirmation.

关 键 词：匹维溴铵 氟哌噻吨美利曲辛 肠易激综合征 META分析 随机对照试验 

分 类 号：B849[哲学宗教—应用心理学] R587.1[哲学宗教—心理学]