担子菌类真菌新产物研究进展  

Advances in the New Product Research of Basidiomycota

作　　者：巩婷[1] 温艳华[1] 陈尔东[1,2] 朱平[1] 

机构地区：[1]天然药物活性物质与功能国家重点实验室&国家卫生和计划生育委员会天然药物生物合成重点实验室中国医学科学院北京协和医学院药物研究所,北京100050 [2]哈尔滨商业大学药学院,哈尔滨150076

出　　处：《菌物研究》2017年第2期89-111,共23页Journal of Fungal Research

基　　金：中国医学科学院医学与健康科技创新工程重大协同创新项目(2016-I2M-002)

摘　　要：许多大型药用担子菌被发现具有抗癌、杀菌、降糖、降血脂等活性,成为药物开发的新潜在资源,深受人们青睐。文中对2010年以来的担子菌新结构活性产物根据活性类型进行综述,特别关注了2014年至今中国作者的研究,重点描述次级代谢产物的结构及生物活性。Many medicinal fungi of Basidiomycota have showed broad pharmacological activities such as anti-cancer, anti-bactericidal, hypoglycemic, anti-hyperlipidemic effects, which become potential new resources for the drug discovery. This review summarizes research progress on the structurally new active products identified from these higher fungi since 2010, and the related products are classified based on their types of the pharmacological activities. More attention is paid on the structures and biological activities of some important secondary metabolites.

关 键 词：担子菌 次级代谢产物 新结构 活性 

分 类 号：Q949.329[生物学—植物学] O629[理学—有机化学]