黄芪抗脂质过氧化作用的研究  

Studies of the Anti-lipid Peroxidation Effect of Radix Astragali

作　　者：张燕燕[1] 颜敏[2] 文学明[1] 

机构地区：[1]湖北药检高等专科学校,武汉430064 [2]武汉钢铁集团公司职工总医院内科,430080

出　　处：《医药导报》2002年第9期542-543,共2页Herald of Medicine

摘　　要：目的 :探讨黄芪抗脂质过氧化作用。方法 :实验小鼠给予黄芪浓缩液后 ,检测肝匀浆、脑匀浆、血清中过氧化脂质 (LPO)、超氧化物歧化酶 (SOD)、硒 (Se)的含量变化 ,心肌组织中脂褐素的含量变化。结果 :黄芪对小鼠肝匀浆、脑匀浆中脂质体外生成以及对小鼠血清中LPO水平、心肌脂褐素含量有显著抑制作用 (P <0 .0 5 )。而对SOD活性有明显的激活作用 (P <0 .0 5 )。并能增强机体组织中硒含量。结论 :黄芪能阻止自由基引起的过氧化反应 ,减少自由基对生物膜的损害 。Objective:To probe into the anti lipid peroxidation effect of radix astragali . Methods:After mice had been given concentrated solution of radix astragali through stomach tubes, the contents of lipid peroxide (LPO), superoxide dismutase (SOD) and selenium (Se) in the liver, brain and serum,as wells the content of lipofuscin in the myocardium were determined. Results: Radix astragali was shown to have a remarkable inhibitory effect on the in vitro lipid formation in homogenates of the liver and brain, as well as on the serum LPO level and the lipofuscin content in the myocardium( P <0.05). The SOD activity however, was significantly enhanced( P <0.05) and the Se content in the body tissues was increased by radix astragali . Conclusion: Radix astragali was found to prevent peroxidation induced by free radicals, and alleviate biomembrane impairment caused by free radicals. It seems therefore that radix astragali may have an anti senility effect.

关 键 词：黄芪 抗脂质过氧化作用 研究 硒 小鼠 中药 

分 类 号：R285.5[医药卫生—中药学]