Advances in Negative Regulatory Mechanisms of Sox9 Gene Expression during Cartilage Development  

软骨发育过程中负调控Sox9基因表达机制研究进展（英文）

作　　者：刘庆珍[1] 吴尽[1] 邳晓盟 肖慧[1] 刘学东[1] 郑冬[1] 

机构地区：[1]东北林业大学野生动物资源学院,黑龙江哈尔滨150040

出　　处：《Agricultural Science & Technology》2017年第6期1038-1041,共4页农业科学与技术（英文版）

基　　金：Supported by National Natural Science Foundation(31671283);Fundamental Research Fund for the Central Universities(2572014EA05)~~

摘　　要：As the main regulator of cartilage development, Sox9 gene can initiate transcription and expression of various enzymes and protein genes required for car- tilage growth and development. During this process, the expression and function of Sex9 are also regulated by a variety of factors and signaling pathways. More re- search is concerned about the positive regulation. At present, some studies dis- closed that negative regulation of Sox9 expression existed unique mechanisms. This study will discuss and summarize the negative regulatory mechanism of Sox9 gene by microRNA, NF-κB, Wnt, Notch and other factors and signaling pathways, in or- der to provide the basic framework for further investigating the expression and func- tion of Sox9 in cartilage development.Sox9基因是软骨发育过程中的主要调控因子,可以启动软骨生长发育所需的多种酶和蛋白基因的转录表达。在这个过程中,Sox9基因的表达和功能也受到多种因子和信号通路的调控。更多的研究关注其中的正调控,目前部分研究揭示负调控Sox9基因表达具有独特的作用机制。本文从micro RNA、NF-κB、Wnt、Notch等因子和信号通路对Sox9基因的负调控机制进行论述和总结,以期为软骨发育中Sox9的表达和功能深入研究提供基础框架。

关 键 词：Cartilage development Soxg MICRORNA NF-ΚB WNT NOTCH 

分 类 号：Q344[生物学—遗传学]