不同结构两亲性嵌段共聚物的合成、药物负载及释放行为研究  

Amphiphilic polymers with different structures:synthesis,drug loading and release behavior

作　　者：宋晓婉 张玉娇[1] 陈鹏[1] 曹明[1] 夏茹[1] 钱家盛[1] 胡添龙 

机构地区：[1]安徽大学化学化工学院,安徽省绿色高分子材料重点实验室,安徽合肥230601

出　　处：《安徽大学学报（自然科学版）》2017年第4期83-90,共8页Journal of Anhui University(Natural Science Edition)

基　　金：安徽大学博士启动基金资助项目(J01001319);安徽大学大学生创新创业训练计划项目

摘　　要：采用阴离子活性聚合(AROP)的方法分别合成3种不同结构的两亲性嵌段共聚物:线型共聚物聚乙氧基乙基缩水甘油醚-聚乙二醇(PEEGE-PEO-(OH))、星型聚合物PEEGE-PEO-(OH)_3以及类树枝状聚合物PEEGE-PEO-(OH)_(24).通过~1H-NMR及GPC等手段对聚合物的结构进行表征.采用透析法制备负载阿霉素的聚合物胶束,通过透射电镜(TEM)和动态光散射(DLS)对胶束的形貌及尺寸进行表征.结果表明:3种胶束均具有球形结构;与线型及星型聚合物相比,两亲性类树枝状聚合物具有最高的载药效率与载药量;体外药物释放结果显示3种聚合物均具有pH敏感释放特性,且类树枝状表面致密结构可降低药物在中性环境下的释放率.By using living anionic ring opening polymerization （AROP） method, amphiphilic linear copolymer poly （ethoxy ethyl glycidyl ether）-poly （ ethylene oxide） （PEEGE-PEO- （OH））, star copolymer PEEGE-PEO-（OH）3 and dendrimer-like copolymer PEEGE-PEO- （OH）24 were prepared. All the synthetic copolymers were characterized by ^1H-NMR and GPC. The drug-loaded polymer micelles were prepared by a dialysis method. The morphology and the size of the micelles were investigated by transmission electron microscopy （TEM） and dynamic light scattering （DLS）. The results showed that the morphology of three polymeric micelles were spherical. Compared with the linear and star polymers, amphiphilic dendrimers had the highest drug loaded content and encapsulation efficiency; in vitro drug release results showed that three kinds of the polymers had pH sensitive release characteristics. In addition, dendrimer-like polymers with high dense surface structure could reduce the release rate of the drug in the neutral environment.

关 键 词：阴离子活性聚合 两亲性聚合物 聚合物胶束 药物释放 

分 类 号：O631.5[理学—高分子化学]