葡萄糖敏感苯硼酸基高分子纳米药物传输体系  

Phenylboronic Acid-Based Glucose-Sensitive Polymer Nanocarriers Used as Drug Delivery Systems

作　　者：黄琼卫 赵丽[2] 宋之明[3] 冯祥汝[4] 王清[1] 丁建勋[4] 

机构地区：[1]吉林大学中日联谊医院,长春130033 [2]吉林建筑大学材料科学与工程学院,长春130118 [3]吉林大学白求恩第一医院,长春130021 [4]中国科学院长春应用化学研究所,生态环境高分子材料重点实验室,长春130022

出　　处：《应用化学》2017年第7期733-743,共11页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(51403075;51673190;51303174;51390484);吉林省科学发展规划项目(20140520050JH;20170520153JH)资助~~

摘　　要：近年来,智能葡萄糖敏感自调式药物传递系统备受关注。这种智能药物释放系统能够模拟胰腺分泌胰岛素的生理模式而精准调控药物释放并控制血糖水平,在糖尿病治疗中具有良好的应用前景。其中,苯硼酸(PBA)功能化的葡萄糖敏感高分子纳米载体成为近年来的研究热点之一。该类材料具有体系稳定、可长期储存、可逆的葡萄糖敏感性能等优势。根据响应因素不同,葡萄糖敏感药物传递系统可分为pH响应、温度响应和光响应等类型。本文重点介绍了基于PBA的葡萄糖敏感高分子纳米药物载体的发展过程、性能和应用,并对该领域的发展前景进行了展望。Recently, the smart glucose-sensitive self-regulated drug delivery systems have attracted extensive attention. These smart drug delivery platforms can mimic the physiological model of pancreatic insulin secretion with a timely precise drug dose to control the blood glucose level effectively, and has broad application prospects in the treatment of diabetes. Phenylboronic acid （PBA）-functionalized glucose-sensitive polymer nanocarriers have been studied widely and have great stability, long term storability, and reversible glucose-sensitivity. According to response factors, there are pH-,＇ temperature-, and light-responsive nanocarriers for glucose-sensitive drug delivery. This review covers the development, properties, and applications of glucose sensitive nanocarriers based on PBA, and the prospects are predicted.

关 键 词：葡萄糖敏感 苯硼酸 高分子纳米载体 药物传递 糖尿病治疗 

分 类 号：O631.3[理学—高分子化学]