金属纳米颗粒神经发育毒性研究进展  

Research progress in neurodevelopmental toxicity of metal nanoparticles

作　　者：管磊剑 徐凯旋[1] 李宁宁[1] 王心如[1] 吴笛[1] 

机构地区：[1]南京医科大学公共卫生学院现代毒理学教育部重点实验室,江苏南京211166

出　　处：《中国公共卫生》2017年第6期1018-1023,共6页Chinese Journal of Public Health

基　　金：国家自然科学基金(81470150);留学回国人员科研启动资金

摘　　要：随着纳米技术的飞速发展,金属纳米颗粒在不同行业的广泛应用,越来越多的研究开始关注其生物安全性。经母体暴露后,金属纳米颗粒因其独特的理化性质,可穿过胎盘屏障和血脑屏障,到达子代中枢神经系统并影响其发育。大量研究表明大脑是金属纳米颗粒作用的重要靶器官之一,其中损伤最严重的大脑区域是海马区。With rapid development of nanotechnology in recent years,metal nanoparticles are widely used in various industries.The biological safety of metal nanoparticles has received more and more attention,and has become a hot topic.Due to their unique physical and chemical properties,metal nanoparticles can cross the placental barrier and the blood-brain barrier to reach central nervous system of offspring and thus affect their development after prenatal exposure.Numerous studies showed that brain is one of the most important target organs of metal and metal oxide nanoparticles and hippocampus has been affected most seriously among the brain regions.This review elaborates neurodevelopmental toxicity of metal nanoparticle and introduces the latest research progress in this area.

关 键 词：金属纳米颗粒 神经发育毒性 行为 海马区 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]