降压0号治疗高血压对抑郁情绪的影响  

Influence of Anti-hypertension No.0 on Depression in Treatment of Hypertension

作　　者：曹亚英 武轶群[1] 秦雪英[1] 任涛[2] 胡永华[2] 

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,100191 [2]北京大学公共卫生学院,100191

出　　处：《医学研究杂志》2017年第6期56-59,共4页Journal of Medical Research

基　　金：国家"十一五"科技支撑项目[2006BAI01A03-(16)]

摘　　要：目的研究降压0号对高血压患者抑郁情绪的影响。方法采用现场实验的方法,将研究对象分为降压0号组和常规治疗组,进行为期1年的降压治疗。研究对象在基线和随访1年末均自填衡量抑郁程度的Zung量表。结果降压0号组和常规治疗组分别纳入1445例和1414例研究对象。随访1年末两组血压达标率分别为80.6%和81.8%(P=0.439)。随访期间,两组量表评分均略有增加(P均<0.05)但变化幅度小且差异无统计学意义(P=0.429),两组有抑郁倾向者比例均无明显变化(P均>0.05)。结论与其他常规降压药物相比,未发现降压0号治疗高血压对患者的抑郁情绪有明显影响。Objective To explore the influence that anti - hypertension No. 0 might exert on depression in the treatment of hyperten- sion. Methods Participants were divided into anti - hypertension No. 0 group and control group taking other antihypertensive agents in a field trial, and were followed up for one year. Zung Self - Rating Depression Scale was took both at baseline and one year after by partici- pant themselves, which was used for measuring depression level. Results A total of 1445 participants were recruited in anti - hyperten- sion No. 0 group and 1414 in control group. After one year of treatment, the control rates of hypertension were 80.6% and 81.8% in anti - hypertension No. 0 group and control group, respectively （P = 0. 439）. During follow - up, the Zung Scale score increased slightly in both anti - hypertension No. 0 group and control group （ both P 〈 0.05 ） , without significant differences between the two groups （P = 0. 429）. No significant differences were observed in the percentages of participants having depressive tendency in these two groups （ both P 〉 0.05）. Conclusion Compared with other conventional medicines for hypertension, no significant influence on depression was found for hypertensive patients taking Anti - hypertension No. 0.

关 键 词：降压0号 抑郁 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]