激活素A对胎龄小于34周早产儿脑损伤的早期预测价值  

Predictive Value of Activin A in Early Brain Injury in Preterm Infants

作　　者：黄玮玲 卢红艳[1] 王秋霞[1] 常明[1] 张强[1] 

机构地区：[1]江苏大学附属医院儿科,镇江212000 [2]咸宁市中心医院湖北科技学院附属第一医院新生儿科,437100

出　　处：《医学研究杂志》2017年第6期99-101,113,共4页Journal of Medical Research

基　　金：江苏省科技创新与成果转化专项基金资助项目(生命健康科技BL2012058)

摘　　要：目的探讨脐血及羊水激活素A对早产儿脑损伤的早期预测价值。方法选取早产儿98例,根据头颅影像学检查分为脑损伤组和无脑损伤组(对照组),其中脑损伤组又分为轻度脑损伤组和重度脑损伤组。采用酶联免疫吸附试验检测脐血及羊水激活素A水平,并比较脐血、羊水激活素A水平在脑损伤组和对照组、轻度和重脑损伤组之间的差异。结果脑损伤组脐血及羊水激活素A水平均明显高于对照组(P<0.05)。重度脑损伤组脐血及羊水激活素A水平均明显高于轻度脑损伤组(P<0.05)。以27.49ng/dl为截断值,脐血激活素A预测脑损伤的敏感度为86.8%,特异性为91.7%。羊水激活素A以28.33ng/dl为截断值预测脑损伤的敏感度为68.4%,特异性为73.3%。结论激活素A对早产儿脑损伤的早期预测及严重程度评估具有一定价值。Objective To explore the predictive value of umbilical cord blood and amniotic fluid activin A in early brain injury in preterm infants. Methods Totally 98 cases of premature infants were divided into brain injury group and control group according to the cranial imaging examination,and the brain injury group was further divided into mild brain injury group and severe brain injury group. Ac- tivin A levels of umbilical cord blood and amniotic fluid were detected by ELISA,then the comparisons of activin A levels between brain injury group and control group,mild and severe brain injury group were implemented,to finding out their differences. Results Activin A levels of umbilical cord blood and amniotic fluid in brain injury group were significantly higher than those in the control group （P 〈 0. 05）. Activin A levels of umbilical cord blood and amniotic fluid in the severe brain injury group were significantly higher than in the mild brain injury group （P 〈 0.05 ）. At a cut -off of 27.49ng/dl, the sensitivity and specificity of cord blood Activin A in predicting pre- mature brain injury were 86.8% and 91.7% ,respectively. At a cut - off of 28.33ng/dl,the sensitivity and specificity of amniotic fluid ac- tivin A in predicting premature brain injury were 68.4% and 73.3% ,respectively. Conclusion Activin A may have a certain value for the early prediction and severity assessment of brain injury in preterm infants.

关 键 词：激活素A 脑损伤 早产儿 

分 类 号：R72[医药卫生—儿科]