脂蛋白相关磷脂酶A_2水平与冠状动脉疾病严重程度相关性  

Relationship of the Lipoprotein-associated Phospholipase A_2 Activity with the Severity of Coronary Artery Diseases

作　　者：张浩 杨志健 王连生 张定国 

机构地区：[1]南京医科大学第一附属医院心血管内科,210009

出　　处：《医学研究杂志》2017年第6期147-150,共4页Journal of Medical Research

摘　　要：目的探讨国人血浆脂蛋白相关磷脂酶A_2(LP-PLA_2)活性与冠状动脉疾病(coronary heart disease,CAD)的严重程度相关性。方法对176例疑似有CAD的患者进行冠状动脉造影,观察冠状动脉狭窄程度。根据冠状动脉狭窄的支数,分为对照组(病变支数为0)、单支病变组、多支病变组(病变支数为2支及以上);根据临床表现、心电图结果、心肌标志物和冠状动脉造影的结果,患者分为对照组(排除CAD)、稳定型心绞痛、不稳定型心绞痛以及急性心肌梗死组,用统计学方法比较各组之间LP-PLA_2水平的不同。结果 LP-PLA_2的活性随着冠状动脉病变支数增加而增加;急性心肌梗死组和不稳定型心绞痛组LP-PLA_2活性显著高于对照组和稳定型心绞痛组。结论血浆LP-PLA_2水平与冠状动脉疾病的严重程度呈正相关。Objective To investigate whether lipoprotein - associated phospholipase A2 （LP - PLA2） activity is positively - associ- ated with the severity of coronary artery diseases（CAD）. Methods Totally 176 patients who were suspected to have coronary artery dis- eases were performed coronary angiography （CAG） to figure out the severity of coronary artery. According to the number of diseased coro- nary branches, 176 patients were divided into three groups： control group （ no diseased coronary branches） , single - vessel stenosis group, multiple vessels stenosis group （ ≥2 diseased coronary branches）. According to clinical presentation, electrocardiography, cardiac biomarker, and CAG result, all patients were divided four groups： control （excluded CAD） , stable angina （SA） , unstable angina （UA） and acute myocardial infarction （AMI） groups. The level of LP - PLA2 were compared statistically among the subgroup. Results The level of LP - PLA2 increased with the increasing number of diseased coronary branches. The levels of LP - PLA2 in AMI and UA groups was significantly higher when compared with control and SA groups. Conclusion The activity of lipoprotein - associated phospholipase A2 ispositively - associated with the severity of coronary artery diseases.

关 键 词：脂蛋白相关磷脂酶A2 冠状动脉疾病 冠脉造影 

分 类 号：R5[医药卫生—内科学]