慢型克山病患者认知能力及相关影响因素分析  

Cognitive investigation and analysis of related factors on patients with chronic Keshan disease

作　　者：管翠玲[1] 王秀红[2] 王园园[2] 陈凡金[3] GUAN Cui-ling WANG Xiu-hong WANG Yuan-yuan CHEN Fan-jin(Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250022, Chin)

机构地区：[1]山东大学附属省立医院,济南250022 [2]山东省地方病防治研究所 [3]邹城市疾病预防控制中心

出　　处：《中国地方病防治》2016年第12期1321-1324,共4页Chinese Journal of Control of Endemic Diseases

基　　金：山东省医药卫生科技发展计划项目(2013WS0176)

摘　　要：目的评估慢型克山病患者的认知功能状况及其相关影响因素。方法对符合《克山病诊断》标准的65例慢型克山病患者进行蒙特利尔认知评估量表(MoCA)认知功能评估,并选择62例病区健康人作为对照,收集受检人群的一般资料和临床资料,以患者认知状况为因变量,相关因素为自变量进行多元线性逐步回归分析。结果 (1)慢型克山病患者和病区健康人MoCA评分分别为(21.72±5.31)分与(24.39±4.47)分,两者比较差异有统计学意义(P<0.05);同时均低于标准界值26分,其中以延迟回忆、抽象力和视空间与执行功能受损最严重。(2)患者组不同心功能分级、患病时间及受教育年限的MoCA得分差异有显著统计学意义(P<0.01)。(3)多元线性逐步回归分析显示,心功能分级、受教育年限、病程及经济状况被纳入MoCA总分回归方程,F=26.554,P=0.000,决定系数(R2)=0.564,调整R2=0.543。结论慢型克山病患者认知功能受到不同程度的损害,NYHA心功能分级、受教育年限、病程及经济状况是相关影响因素,其中前两项是重要因素,应引起克山病防治工作者的高度重视。Objective To evaluate the cognitive ability and its related influencing factors on patients with chronic Keshan disease. Methods 65 patients with chronic Keshan disease which conformed to the standard of Keshan disease diagnosis were evaluated by Montreal cognitive assessment （MoCA） scale, and 62 cases of healthy people in Keshan disease areas were selected as control General data and clinical data of tested group were collected, too. With cognitive status of patients as dependent variable, the related factors as the independent variable for multiple linear stepwise regression analysis. Results①The MoCA scores of patients and healthy people were respectively （21.72±5.31） points and （24.39±4.47） points, which the difference was statisti- cally significant （P〈0.05）. Both below the standard boundary value of 26 points at the same time, and the delay memory, abstract ability and visual spatial and executive function most severely damaged. ②The MoCA scores of patients were difference with different cardiac function classification, sick time or with fixed number of years of education, and had statistical significance （P〈0. 01）. ③Multiple linear stepwise regression analysis showed that cardiac function grading, fixed number of year of the education, course and economic situation was incorporated into MoCA score regression equation, F = 26. 554, P = 0.000, determination coefficient （ R2） = 0. 564, the adjusted R2 = 0. 543. Conclusions The cognitive function of chronic Keshan disease patients were damaged by different degrees. The NYHA heart function classification, the fixed number of year of the education, the course of disease and the economic situation were related influencing factors, and the first two were important factors which should be pay more attention to.

关 键 词：慢型克山病 蒙特利尔认知评估量表 认知功能 影响因素 

分 类 号：R524.3[医药卫生—内科学]