脂联素对慢性阻塞性肺疾病炎症因子、TIMP-1、TGF-β1的影响  

Effects of adiponectin on inflammatory cytokines,TIMP-1 and TGF-β1 of chronic obstructive pulmonary disease

作　　者：历风元[1] 周少华[1] 朱涟敏[1] 戴宏燕[1] LI Fengyuan ZHOU Shaohua ZHU Lianmin et al(the First Hospital of Nanchang City ,Nanchang,330008, Chin)

机构地区：[1]江西省南昌市第一医院呼吸科,南昌330008

出　　处：《江西医药》2017年第6期485-488,共4页Jiangxi Medical Journal

基　　金：江西省科学技术厅课题项目;编号:20112BBG70070

摘　　要：目的探讨脂联素对COPD大鼠模型炎症因子、TIMP-1、TGF-β1的影响。方法采用熏香烟加气管内注入内毒素法复制COPD大鼠模型,分别给予脂联素干预,检测COPD大鼠模型血清中炎症因子、脂联素水平、TIMP-1、TGF-β1的表达。结果对照组脂联素水平明显高于COPD模型组(P<0.05),COPD模型组大鼠血清中的炎症因子(IL-6、TL-8、TNF-a)显著高于其他两组,干预组大鼠血清中炎症因子要低于COPD模型大鼠,稍高于对照组,三组间比较P<0.05;COPD模型组中的TGF-β1表达显著增高,TIMP-1的表达却低于对照组,COPD干预组TGF-β1较正常对照组组低,TIMP-1较正常对照组高,三组间比较P<0.01。结论脂联素能够降低COPD大鼠IL-6、TL-8、TNF-a的水平,具有抗炎症作用;能够降低TGF-β1的表达,升高TIMP-1的表达。Objective To investigate the effect of adiponectin on inflammatory cytokines,TGF-β1 and TIMP-1 in rat model of COPD. Methods The rat model of COPD was established by smoked cigarettes and injected endotoxin into the trachea of COPD, and the serum levels of inflammatory factors,adiponectin levels,TGF-β1 ,and TIMP-1 were detected. Results Adiponectin levels of control group were significantly higher than that of C OPD model group （P〈0.05）,inflammatory eytokines（IL-6 ,TL-8 ,TNF-α） of COPD model group were significantly higher than those in other two groups,the serum levels of inflammatory factors in the intervention group were lower than that in model group,but slightly higher than that in control group,P〈0.05;the expression of TGF- β1 in C OPD model group was significantly increased,the expression of TIMP-1 was lower than that in control group,the expression of TGF-β1 in COPD intervention group was lower than that in control group;TIMP-1 was higher than that in normal control group,P〈0.01. Conclusion Adiponectin can decrease the levels of IL-6,TL-8 ,TNF-α,which has anti-inflammatory effect;and it can decrease the expression of TGF-β1 and increase the expression of TIMP-1.

关 键 词：脂联素 慢性阻塞性肺疾病 炎症因子 TIMP-1 TGF-Β1 

分 类 号：R563.9[医药卫生—呼吸系统]