上皮间质转化在干细胞诱导分化及肿瘤发生中的作用  

Role of epithelial-mesenchymal transition in stem cell differentiation and tumorigenesis

作　　者：张风波[1,2,3,4] 李玲丽[1,2,3,4] 江欣星 马燕琳[1,2,3,4] 李崎[1,2,3,4] Zhang Feng-bo Li Ling-li Jiang Xin-xing Ma Yan-Lin Li Qi(Hainan Medical University, Haikou 571199, Hainan Province, China Affiliated Hospital of Hainan Medical University, Haikou 571199, Hainan Province, China Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Haikou 571199, Hainan Province, China the Key Laboratory of Tropical Diseases and Translational Medicine of The Ministry of Education, Haikou 571199, Hainan Province, China)

机构地区：[1]海南医学院,海南省海口市571199 [2]海南医学院附属医院,海南省海口市571199 [3]海南省人类生殖与遗传重点实验室,海南省海口市571199 [4]热带病转化医学教育部重点实验室,海南省海口市571199

出　　处：《中国组织工程研究》2017年第17期2753-2758,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81460034;81060175);科技部国家国际科技合作专项项目(2014DFA30180);海南省自然科学基金(812201);海南省普通高等学校研究生创新科研课题(hys2015-61)~~

摘　　要：背景:上皮间质转化与胚胎发育、干细胞诱导分化、损伤组织修复、肿瘤发生发展密切相关。目的:综述上皮间质转化在干细胞诱导分化和肿瘤发生中的作用。方法:应用计算机检索2001至2016年CNKI数据库和Pub Med数据库中相关文献,检索关键词为"上皮间质转化,干细胞,肿瘤/癌;epithelial-mesenchymal transition,Stem cell,tumor/cancer",共检索到文献1 249篇,最终纳入符合标准的文献50篇。结果与结论:上皮间质转化与干细胞分化和肿瘤细胞的发生、发展密切相关,在干细胞分化和肿瘤侵袭转移中均发现了上皮间质转化相关标志因子。上皮间质转化受多种调控因素的影响,而干细胞分化和肿瘤的发生发展也是多程序多步骤的复杂过程。虽然现在对上皮间质转化与这二者之间的发生及部分调节机制有了比较透彻的了解,但对整个复杂调控网络的了解还是远远不够的。如何更深入了解上皮间质转化的发生及调控机制网,以及如何更好地把研究成果安全有效地应用于临床预防、诊断及治疗,将会成为现在及未来大家共同的努力目标。BACKGROUND： Epithelial-mesenchymal transition is closely related to embryonic development, stem cell -induced differentiation, injury tissue repair and tumorigenesis. OBJECTIVE： To review the role of epithelial-mesenchymal transition in stem cell differentiation and tumorigenesis. METHODS： The CNKI and PubMed databases were retrieved by computer for relevant literatures published from 2001 to 2016 with the key words of ＂epithelial-mesenchymal transition, stem cell , tumor/cancer＂ in Chinese and English, respectively. 1249 articles were retrieved in total, and 50 papers were suitable for final analysis. RESULTS AND CONCLUSION： The epithelial-mesenchymal transition is closely associated with stem cell differentiation, tumorigenesis and tumor progression. The emergence of epithelial-mesenchymal transition related markers were found in stem cell differentiation and tumor invasion and metastasis. Epithelial-mesenchymal transition is affected by a variety of regulatory factors, and the differentiation of stem cells and the occurrence and development of tumor are also multi-procedural and multi-step complex processes. Although we have a more thorough understanding on occurrence mechanisms and some regulation mechanisms of epithelial-mesenchymal transition for stem cell differentiation and tumorigenesis, the understanding of the complex regulatory network is still not enough. How to have a deeper understanding of the occurrence and regulation mechanisms of epithelial-mesenchymal transition, and how to apply research results safely and effectively in the clinical prevention, diagnosis and treatment will be the common goal of us now and in the future.

关 键 词：干细胞 肿瘤干细胞 上皮间质转化 分化 肿瘤 分子机制 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]