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作 者:王炳晨 江明[1,2] Wang Bing-chen Jiang Ming(Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medica University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China Xinjiang Research Institute of Hematology, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China)
机构地区:[1]新疆医科大学第一附属医院血液病中心,新疆维吾尔自治区乌鲁木齐市830054 [2]新疆维吾尔自治区血液病研究所,新疆维吾尔自治区乌鲁木齐市830054
出 处:《中国组织工程研究》2017年第17期2783-2788,共6页Chinese Journal of Tissue Engineering Research
基 金:国家自然科学基金(81060050)~~
摘 要:背景:异基因造血干细胞移植的本质是免疫细胞的移植,其治疗作用主要依靠移植物抗白血病效应,但其伴随的移植物抗宿主病增加了患者的死亡率,影响疗效。目前研究者提出了多种减轻移植物抗宿主病同时增强移植物抗白血病效应的方法,但各有优缺点及争议点,故对两者之间的关系及分离方法尚需进一步深入的研究。目的:综述异基因造血干细胞移植后减轻移植物抗宿主病而加强或不降低移植物抗白血病效应的研究现状。方法:由第一作者检索万方、CNKI、Pub Med数据库,检索时间为2000至2016年,英文检索词为"hematopoietic stem cell transplantation,graft versus leukemia,graft-versus-host disease,donor lymphocyte infusion,regulatory T cell,natural killer cell,mesenchymal stem cell",查阅近年增强移植物抗白血病效应及减低移植物抗宿主病的相关文献。结果与结论:最终纳入42篇文献。目前有关移植物抗白血病效应和移植物抗宿主病的关系及各自的发生机制仍不十分明确,有关两者分离方法虽多,但各有优缺点及争议点,尚未有统一的最优方案,需要进一步研究。BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the essence of immune cell transplantation, its curative effect mainly depends on graft-versus-leukemia (GVL) effect, but its accompanying graft-versus-host disease (GVHD) can increase mortality and affect the therapeutic efficacy. Until now, researchers have proposed a variety of ways to reduce GVHD but enhance or maintain GVL. However, these methods have their own advantages, disadvantages and controversial points. So their relationship and separation methods still need further studies. OBJECTIVE: To summarize the current status of research about separation methods of GVHD and GVL after allo-HSCT. METHODS: Using "hematopoietic stem cell transplantation, graft versus leukemia, graft-versus-host disease,donor lymphocyte infusion, regulatory T cell, natural killer cell, mesenchymal stem cell" as key words, we retrieved Wanfang, CNKI and PubMed databases (2000-2016) by computer. RESULTS AND CONCLUSION: We finally reviewed 41 literatures about enhancing GVL and reducing GVHD in recent years. At present, the relationship between GVHD and GVL, and their respective mechanisms are still unclear. There are many methods to separate GVHD and GVL, but these methods have their own advantages and disadvantages. The best solution has not yet been unified, and still needs further study.
关 键 词:干细胞 移植 异基因造血干细胞 移植物抗宿主病 移植物抗白血病效应 供者淋巴细胞输注 调节性T细胞 间充质干细胞 NK细胞 国家自然科学基金
分 类 号:R318[医药卫生—生物医学工程]
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