可吸收防粘连膜的应用研究与未来展望  

Research progress of absorbable anti-adhesion membranes

作　　者：陈灶妹[1,2,3] 李茹冰[1,2] Chen Zao-mei Li Ru-bing(Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China Guangzhou Key Laboratory of Rational Drug Use for the Elderly with Chronic Disease, Guangzhou 510010, Guangdong Province, China Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong Province, China)

机构地区：[1]解放军广州军区广州总医院药剂科,广东省广州市510010 [2]广州市老年慢病患者合理用药重点实验室,广东省广州市510010 [3]广东药科大学,广东省广州市510006

出　　处：《中国组织工程研究》2017年第18期2920-2926,共7页Chinese Journal of Tissue Engineering Research

基　　金：广东省产学研专项(2012B091100170);广州市科技计划项目(201509010012)~~

摘　　要：背景:外科手术后组织发生粘连会引起严重的并发症,致使机体功能缺失,深深影响着患者的生活质量。因此,在外科手术后亟需预防组织粘连的发生。目的:对现有的防粘连膜研究成果进行综合分析,深入了解防粘连膜目前所存在的优势与缺点。方法:应用计算机检索2005至2016年PubM ed数据库、CNKI等数据库收录的与防粘连材料或产品相关的文献。英文检索词为"absorbable membrane,absorbability,anti-stiction,anti-adhesion,electrospinning,electrospun,nano-fiber,anti adhesion membrane/film,biodegradability",中文检索词为"可吸收性,防粘连,静电纺丝,纳米纤维,防粘连膜,生物可降解性",最后选取42篇文献进行综述。结果与结论:(1)防粘连膜能有效预防术后组织粘连的发生,加速患者愈合,提高其生活质量;(2)采用流延成膜法制得的膜因脆性大、韧性较差等缺点,限制了其在临床上的应用;而利用静电纺技术制成的防粘连膜柔软性高、组织黏附性好,在组织愈合过程中不但有防粘连作用,且具有良好的组织相容性,在术后可自行降解或吸收,其具有潜在的相对优势;(3)静电纺丝技术制备的纳米纤维产品,因具有表面积大、孔隙率高、纤维纤度细、机械强度好等优良特性,在生物医学领域倍受人们关注,此类产品在创伤修复、生物组织工程、可吸收防粘连膜等方面也得到了广泛的应用。BACKGROUND： Postoperative tissue adhesions can cause serious complications, resulting in the loss of body function, which deeply affects the patient＇s quality of life, and brings great threat to the life and health. Therefore, it is necessary to prevent postoperative tissue adhesion. OBJECTIVE： To summarize the achievement of absorbable anti-adhesion membrane in recent years, and to gain further insight into its advantages and disadvantages. METHODS： Pub Med and CNKI were searched for relevant articles about anti-adhesion materials or products published from 2005 to 2016. The key words were ＂absorbable membrane, absorbability, anti-stiction, anti-adhesion, electrospinning, electrospun, nano-fiber, anti adhesion membrane/film, biodegradability＂ in Chinese and English, respectively. In accordance with the inclusion and exclusion criteria, 42 articles were reviewed. RESULTS AND CONCLUSION： Anti-adhesion membranes can effectively prevent postoperative adhesions, accelerate wound healing, and improve patients＇ quality of life. Bio-films, prepared using the film casting method, have the shortcomings of brittleness and poor toughness, which limit its clinical application. However, the anti-adhesion membrane made by electrostatic spinning technology has the advantages of high plasticity and good adhesiveness. It not only has the function of preventing adhesion, but also has a good biocompatibility during the tissue healing process. More fortunately, it can be degraded or absorbed in the postoperative period, showing its potential advantages. Nano-fiber products prepared by electro-spinning technology possess excellent characteristics, such as specific surface-area, high porosity, strong adsorption, fine fibrousness, excellent mechanical properties and so on, which have attracted much attention in the biomedical field. Such products have been also widely used in wound repair, tissue engineering and absorbable anti-adhesion membranes.

关 键 词：生物材料 纳米材料 防粘连膜 可吸收性 防粘连 静电纺丝 纳米纤维 生物可降解性 

分 类 号：R318[医药卫生—生物医学工程]