国内外胰管支架材料发展状况及临床应用  

Current development and clinical application of pancreatic stents

作　　者：王江[1] 刘凯[1] Wang Jiang Liu Kai(Department of Hepatobiliary and Pancreatic Surgery, No. 1 Hospital of Jilin University, Changchun 130021, Jilin Province, China)

机构地区：[1]吉林大学第一医院肝胆胰外二科,吉林省长春市130021

出　　处：《中国组织工程研究》2017年第18期2934-2939,共6页Chinese Journal of Tissue Engineering Research

基　　金：吉林省发改委资助(2013C023-6)~~

摘　　要：背景:近年来,随着人们饮食习惯和生活习惯的改变,慢性胰腺炎发病率显著增高,内镜下胰管支架治疗慢性胰腺炎展现出良好的临床前景。目的:介绍各种支架材料的利弊,阐述国内外胰管支架材料发展状况及临床应用。方法:以"慢性胰腺炎,胰管支架"为中文检索词,以"chronic pancreatitis,pancreatic stent"为英文检索词,应用计算机在中国期刊全文数据库和Pub Med数据库检索2005年1月至2016年11月的相关文章,筛选出可用于体内外及临床研究的内镜下新型材料胰管支架。结果与结论:(1)内镜下胰管支架置入作为慢性胰腺炎的有效治疗手段之一,已成为国内外专家的共识,其中胰管支架材料的开发和应用显得尤为重要;(2)根据胰管支架材料的不同,可将胰管支架分为塑料支架、自膨胀金属支架、具有生物可降解性的支架;(3)塑料胰管支架与自膨胀金属胰管支架虽已广泛应用于临床,但其存在支架与胰管契合度欠佳、支架移位且需二次手术取出等问题;(4)生物可降解性的支架材料可在预期时间内于胰管中完全降解,避免了支架置入术后的诸多并发症。故具有生物可降解性的支架材料的开发及应用已成为国内外专家的研究热点。BACKGROUND： In recent years, the morbidity of chronic pancreatitis has been increasing dramatically with lifestyle changes. Fortunately, endoscopic pancreatic stenting for patients with chronic pancreatitis shows favorable clinical prospects. OBJECTIVE： To introduce the advantages and disadvantages of various stent materials and to review thedevelopment and clinical application of pancreatic stents. METHODS： With the key words of ＂chronic pancreatitis, pancreatic stent＂ in Chinese and English, respectively, a computer-based search was performed for articles published in CNKI and Pub Med databases from January 2005 to November 2016. After the initial screening, articles related to endoscopic pancreatic stenting used in vitro, in vivo or in clinic were included. RESULTS AND CONCLUSION： Endoscopic pancreatic stenting has become a recognized treatment for chronic pancreatitis in recent years. Therefore, the development and application of the materials of pancreatic duct stents appear to be particularly important. According to different materials, pancreatic duct stents can be classified into plastic stents, fully covered self-expandable metal stents, and biodegradable stents. The complications, including stent migration and secondary surgery, frequently appear in the clinical use of plastic pancreatic duct stents and self-expandable metal stents, although they have been widely used in clinical practice. Biodegradable pancreatic duct stents can be degraded completely in the pancreatic duct within the expected time, and thereby avoid several complications. Consequently, the exploitation and application of biodegradable pancreatic duct stents have become an issue of concern.

关 键 词：生物材料 材料相容性 慢性胰腺炎 经内镜逆行性胰胆管造影术 胰管支架 生物可降解材料 

分 类 号：R318[医药卫生—生物医学工程]