糜蛋白酶注射治疗腰椎间盘突出症的临床研究  

Clinical study on intrahenial injection with chymotrypsin for treatment of lumbar intervertebral disc herniation

作　　者：许远海[1] 陈丽[1] 朱海峰[1] 李万奎[1] 许超[1] XU Yuanhai CHEN Li ZHU Haifeng LI Wabkui XU Chao(Department of Neurology Medicine, Hospital NO. 154 of PLA, Xinyan,He＇nan 464000,China)

机构地区：[1]中国人民解放军第一五四中心医院神经内科,河南省信阳市464000

出　　处：《微创医学》2017年第3期359-362,共4页Journal of Minimally Invasive Medicine

摘　　要：目的探讨突出物内注射糜蛋白酶治疗腰椎间盘突出症的临床疗效。方法 146例腰椎间盘突出症患者随机分为对照组(71例)和观察组(75例)。对照组突出物内注射胶原酶,观察组突出物内注射糜蛋白酶。出院时评定疗效,出院6个月后回访再一次评定疗效。结果术后第4天评比疗效,对照组总有效率为49.3%(35/71),观察组32.0%(24/75),两组比较,差异有统计学意义(P<0.05)。术后6个月随访评比1次疗效,总有效率对照组为83.1%(59/71),观察组为80.0%(60/75),两组比较,差异无统计学意义(P>0.05)。结论突出物内注射糜蛋白酶治疗腰椎间盘突出症是一种费用低、痛苦小、安全、疗效较好的微创治疗方法。Objective To explore the clinical efficacy of intrahenial injection with chymotrypsin for treatment of lumbar intervertebral disc hemiation. Methods A total of 146 patients with lumber intervertebral disc herniation were randomly divided into control group （ n = 71 ） and observation group （ n = 75 ）. Intrahenial injection with collagenase was performed in the control group and intrahenial injection with chymotrypsin in the observation group. The efficacy was assessed when discharge and follow-up after 6 months of discharge. Results The efficacy was assessed at the fourth day after operation, the total effective rate of the control group and the observation were 49.3% （35/71） and 32.0% （24/75）respectively, and there was significant difference between the two groups（ χ2 = 8. 052, P 〈 0.01 ）. The efficacy was assessed again after 6 months of operation, the total effective rate of the control group and the observation were 83.1% （59/71 ） and 80.0% （60/75）respectively, and there was no significant difference between the two groups （χ2 = 0. 971, P 〉 0.05 ）. Conclusion For lumbar intervertebral disc hemiation, intrahenial injection with chymotrypsin is a minimally traumatic approach with low cost, less pain, safety and good efficacy.

关 键 词：椎间盘移位 椎间盘化学松解术 糜蛋白酶 CT介导 评价观察 

分 类 号：R681.53[医药卫生—骨科学]