CNS中抗原递呈细胞调节T细胞对CNS抗原的应答  

Regulation of T cell responses to CNS antigens by antigen-presenting cells in CNS

作　　者：张剑[1] 田野苹[1] 

机构地区：[1]第二军医大学免疫学教研室,上海200433

出　　处：《中国神经科学杂志》2002年第3期639-642,共4页

基　　金：全军医药卫生科研基金 (0 1MA163 )

摘　　要：在中枢神经系统 (CNS)炎症或损伤时 ,T细胞对CNS抗原的应答启动于外周免疫系统 ,而作用于CNS。CNS中小胶质细胞、星形胶质细胞和血管周围巨噬细胞可作为抗原递呈细胞 ,通过对Th1和Th2细胞的再刺激 ,分泌可溶性因子调节Th1和Th2细胞应答 ,以及与T细胞间相互作用 ,调控Th1细胞和Th2细胞间的平衡 ,从而促进或抑制T细胞应答 。During the inflammation or injury of central nervous syetem (CNS), T cell responses to the CNS antigen,which are initiated by peripheral immune system, act on CNS . Microglia, astrocytes and perivascular macrophages in CNS can act as antigen presenting cells(APCs) and regulate the balance between Th1 and Th2 cells. APCs in CNS improve or suppress the T cell responses and then influence the outcome of the inflammation or injury of CNS through restimulating Th1 and Th2 cells, secreting soluble factors and interacting with T cells. \[

关 键 词：CNS CNS抗原 中枢神经系统 抗原递呈细胞 T细胞 小胶质细胞 星形胶质细胞 免疫应答 

分 类 号：R392.1[医药卫生—免疫学]