小儿中枢神经系统感染中C反应蛋白检测的临床价值  

Clinical value of C-reactive protein detection in children with central nervous infection

作　　者：李先平[1] 黄海波[1] 

机构地区：[1]信宜市人民医院儿科,广东信宜525300

出　　处：《中国中西医结合儿科学》2017年第3期243-245,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的研究分析小儿中枢神经系统感染中C反应蛋白检测的临床价值。方法 2013年1月至2016年1月信宜市人民医院儿科收治住院的中枢神经系统感染患儿88例,其中化脓性脑膜炎38例,病毒性脑膜炎50例。同期选取本院健康体检儿童75例作为对照组。3组研究组对象均进行实验室检验,对比3组血清C反应蛋白、脑脊液C反应蛋白检测水平。结果化脓性脑膜炎组、病毒性脑膜炎组血清C反应蛋白、脑脊液C反应蛋白均高于对照组(P<0.01),并且化脓性脑膜炎组血清C反应蛋白、脑脊液C反应蛋白水平高于病毒性脑膜炎组,差异有统计学意义(P<0.01)。化脓性脑膜炎、病毒性脑膜炎组恢复期血清、脑脊液C反应蛋白水平均低于急性期,并且病毒性脑膜炎组恢复期血清、脑脊液C反应蛋白水平降低幅度大于化脓性脑膜炎组,差异有统计学意义(P<0.01)。结论小儿中枢神经系统感染中C反应蛋白检测有利于鉴别诊断化脓性脑膜炎和病毒性脑膜炎。因血清标本比较容易获得,单独检测血清C反应蛋白可作为小儿中枢神经系统感染疾病重要生化检验指标。Objective To study and analyze the clinical value of C-reactive protein detection in chil- dren with central nervous infection. Methods A total of 88 children with central nervous infection were in- cluded in the study, who were hospitalized in Xinyi People＇s Hospital from Jan. 2013 to Jan. 2016; there were 38 cases of purulent meningitis and 50 cases of viral meningitis. The control group consisted of 75 healthy children in our hospital at the same period. Laboratory tests were performed in these 3 groups of children, and compare the level of C-reactive protein in serum and cerebrospinal fluid. Results The level of C-reactive protein in serum and cerebrospinal fluid in the purulent group and the viral group was higher than that in the control group（P〈0. 01）, and the level in purulent group was higher than that in the viral group, with statistical difference（P〈0. 01）. The serum and cerebrospinal fluid level in both purulent and viral groups at recovery stage was lower than that at acute stage, and the level decrease in viral group was greater than that in purulent stage at recovery stage; there was statistical difference（P〈0.01）. Conclusion The de- tection of C-reactive protein in children with central nervous infection is beneficial to the differentiated diag- nosis of purulent meningitis and viral meningitis. Because it＇s easier to obtain serum samples, the level of se- rum C-reactive protein alone can be used as an important biochemical testing indicator in children with cen- tral nervous infectious disease.

关 键 词：中枢神经系统感染 C反应蛋白 血清 脑脊液 儿童 

分 类 号：R729[医药卫生—儿科]