华南地区人细小病毒B19和Parv4感染与早期自然流产关系  

Relationship between human parvovirus B19 and Parv4 infection and spontaneous abortion in Southern China

作　　者：余燕[1] 欧国灯[1] 杜耀民[2] 梁蔚阳[1] 邓锋[1] YU Yan＇ OU Guodeng DU Yaomin LIANG Weiyan DENG Feng(Euangdong Institute for Drug Control,Euangzhou 510180,China Guangdong General Hospital,Guangzhou 510180,China)

机构地区：[1]广东省药品检验所,广东广州510180 [2]广东省人民医院,广东广州510180

出　　处：《中国医药科学》2017年第10期7-10,共4页China Medicine And Pharmacy

基　　金：广东省科技计划项目(2014A020218011;2016A040403076);广州市越秀区科技计划项目(2015PT006)

摘　　要：目的通过对近年来华南地区早期自然流产孕妇的血清样品的B19和Parv4感染状况调查,分析华南地区人细小病毒感染与早期自然流产的关系。方法选取门诊确诊的379例早期自然流产患者,采用q-PCR方法检测B19和Parv4的感染状况及病毒载量,以同期348例人工流产孕妇进行对比,将相关数据进行统计分析。结果华南地区孕妇人群中B19感染率略高于已有调查地区,妊娠期前后B19和Parv4感染与妊娠不良结局有密切关系。结论 Parv4常与B19合并感染,B19指标在很大程度上同时可以反映Parv4的风险。Objective To investigate the relationship between infection and early spontaneous abortion in Southern China,to investigate the serum B19 and Parv4 infection in pregnant women with early spontaneous abortion in recent years. Methods 379 cases of patients with early abortion diagnosed in clinic were selected,The q-PCR method was used to detect infection and virus B19 and Parv4 load.At the same period, 348 cases of artificial abortion of pregnant women were selected as control.The relevant data was statistically analyzed. Results The prevalence of B19 infection in pregnant women in Southern China area is slightly higher than that in the investigated areas. Conclusion The B 19 and Parv4 infection before and after pregnancy are closely related to the adverse pregnancy outeomes.Parv4 often associates with B19 infection. B19 indicators can largely reflect the risk of Parr4.

关 键 词：华南地区 细小病毒 Q-PCR 早期流产 

分 类 号：R714.21[医药卫生—妇产科学]