新生儿持续性肺动脉高压采用西地那非联合硫酸镁治疗效果观察  

Effect observation of sildenafil combined with magnesium sulfate in treatment of persistent pulmonary hypertension of the newborn

作　　者：毕金娥[1] 冯婧[1] 韩静[1] 周翔[1] BI Jin＇e FENG Jing HAN Jing ZHOU Xiang(Department of Neonatal,Longgang District Maternal and Child Health Care Hospital,Shenzhen 518112,China)

机构地区：[1]深圳市龙岗区妇幼保健院新生儿科,广东深圳518112

出　　处：《中国医药科学》2017年第10期39-41,55,共4页China Medicine And Pharmacy

摘　　要：目的观察新生儿持续性肺动脉高压采用西地那非联合硫酸镁治疗效果。方法收取我院110例持续性肺动脉高压患儿,收取时间在2015年2月~2016年3月,分为两组,对照组患儿实施硫酸镁治疗,观察组患儿实施西地那非联合硫酸镁治疗。结果观察组患儿治疗的总有效率、PaCO_2(35.12±4.08)mm Hg、SBP(70.15±9.23)mm Hg、PaO_2(83.12±9.78)mm Hg、SPAP指标(26.01±7.23)mm Hg优于对照组(P<0.05),观察组患儿住院时间、症状消失时间、住院费用、不良反应发生率优于对照组,差异有统计学意义(P<0.05)。结论新生儿持续性肺动脉高压采用西地那非联合硫酸镁治疗具有显著效果。Objective To observe the curative effect of sildenafil combined with magnesium sulfate in treatment of persistent pulmonary hypertension of the newborn. Methods 110 cases of persistent pulmonary hypertension in children in our hospital from February 2015 to March 2016 were selected and randomly divided into two groups.Patients in control group were treated with magnesium sulphate,and patients in observation group were treated with sildenafil combined with magnesium sulfate. Results The total effective rate,PaCO2 （35.12 ± 4.08） mm Hg,SBP（70.15 ± 9.23）mm I-Ig,PaO2 （83.12 ± 9.78） mm Hg,SPAP （26.01± 7.23）mm Hg of the observation group were better than those of the control group （P 〈 0.05）.The hospitalization time,symptom disappearance time,hospitalization cost and adverse reaction rate of observation group were better than the control group （P ~ 0.05）. Conclusion Effect of sildenafil combined with magnesium sulfate in treatment of persistent pulmonary hypertension of the newborn is significant.

关 键 词：新生儿持续性肺动脉高压 西地那非 硫酸镁 效果 

分 类 号：R722.1[医药卫生—儿科]