86例天疱疮临床病例分析  

Clinical analysis of 86 cases of pemphigus

作　　者：王九妹 吴谦[2] 祝琳琳[3] 张建波[1] WANG Jiumei WU Qian ZHU Linlin ZHANG Jianbo(Department of Dermatology, Hongqi Hospital Affiliated to Mudanjiang Medical College, Heilongjiang, Mudanjiang 157011, China Department of Dermatology, Qijiang People＇ s Hospital, Chongqing 401420, China Department of Dermatology, Shenyang Seventh People＇ s Hospital, Liaoning, Shenyang 110000, China)

机构地区：[1]牡丹江医学院附属红旗医院皮肤科,黑龙江牡丹江157011 [2]重庆市綦江区人民医院皮肤科,重庆401420 [3]沈阳市第七人民医院皮肤科,辽宁沈阳110000

出　　处：《中国医药科学》2017年第10期251-253,共3页China Medicine And Pharmacy

摘　　要：目的对比不同给药方案治疗轻重度天疱疮患者的激素初始量、最大控制量、病情控制累计量。探讨影响激素用量的指标及有效激素初始量。方法收集2009年5月~2015年12月我院收治的86例天疱疮患者临床资料,依据治疗方案分为激素治疗组(A组)与激素联合其它药物治疗组(B组);根据皮损评分分为轻度(ABSIS评分≤50分)与重度(ABSIS评分>50分)两组;利用SPSS12.0分析各组数据间差异有无统计学意义。结果轻度组与重度组患者的各对应数据均有统计学差异。B组的激素初始量、最大控制量与A组对应数据的差异均有统计学意义(P<0.05),而病情控制累计量无统计学差异(P>0.05)。结论天疱疮病情轻重是影响患者激素初始量、最大控制量、病情控制累计量的重要因素。激素辅助治疗可有效降低糖皮质激素应用的初始量。Objective To compare the different drug regimens to the initial dosage, maximum dosage, maximum dosage of patients with mild severe pemphigus, and to investigate the effect of hormone dosage and the initial amount of effective hormone. Methods 86 patients with pemphigus treated in our hospital from May 2009 to December 2015 were selected. According to different treatment regimens, they were divided into hormone treatment group （group A） and hormone combined with other drug treatment group （group B）. According to skin lesion score, they were divided into mild group （ABSIS score 〈 50 divided） and severe group and severity （ABSIS score 〉 50）. SPSS12.0 was used to analyze the statistical significance of the differences between the data. Results The difference of the corresponding data in both mild and severe patients were statistically significant. In addition, the difference of the initial dosage, maximum dosage to control disease per day of steroids in both group A and group B was statistically significant （P 〈 0.05）, but there was no statistical difference on cumulative dosage of steroids in both group A and group B （P 〈 0.05）. Conclusion The severity of the disease is an important factor affecting the initial dosage, maximum dosage to control disease per day, cumulative dosage of disease control of steroids. Steroids with adjunctive therapy can effectively reduce the initial dosage of glucocorticoid.

关 键 词：天疱疮 ABSIS评分 激素初始量 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]