自然杀伤细胞与2型糖尿病  

Natural killer cells and type 2 diabetes meilitus

作　　者：周赛君[1] 赵建彤[1] 叶翠[1] 于德民[1] 于珮[1] 

机构地区：[1]天津医科大学代谢病医院糖尿病肾病血液透析科,卫生部激素与发育重点实验室,天津市代谢性疾病重点实验室,300070

出　　处：《国际内分泌代谢杂志》2017年第4期274-276,280,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81600743）;天津市科技支撑重点项目（13ZCDSY01300）;天津市卫生局科技支撑重点项目（15KG101）

摘　　要：近年来，免疫一代谢的相互关系已成为目前新的研究热点之一。自然杀伤细胞（NK细胞）作为固有免疫的主要成员，与2型糖尿病有着密切的联系：一方面，2型糖尿病患者外周血中NK细胞的数量出现异常以及功能出现紊乱，肥胖、胰岛素抵抗和氧化应激均可能参与2型糖尿病患者NK细胞的损伤机制。另一方面，NK细胞不仅可作为联系内脏脂肪炎性反应和脂肪应激的桥梁，参与内脏脂肪胰岛素抵抗，还可作为炎性细胞，促进2型糖尿病患者动脉粥样硬化的形成和进展，从而加剧糖尿病血管损伤。In recent years, the relationship between immune-metabolism has become a new reseach hotspot. Natural killer cells （ NK cells） as one of the main members of innate immunity, is closely related to type 2 diabetes. On one hand, the number and function of NK cells in patients with type 2 diabetes became abnormal, obesity, insulin resistance and oxidative stress may be involved in the pathogenesis of the damage of NK cells in type 2 diabetic patients. On the other hand, NK cells not only can be used as the bridge which connecting inflammation and fat stress in visceral fat and then involved in insulin resistance of visceral fat, but also can be used as inflammatory cells which promote the formation and progress of atherosclerosis in patients with type 2 diabetes, and thereby aggravate diabetic vascular lesions.

关 键 词：2型糖尿病 自然杀伤细胞 胰岛素抵抗 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]