siRNA在抗流感病毒感染中的研究进展  

Progress of siRNA in anti-influenza virus infection

作　　者：宋彦丽[1] 李长贵[1] 

机构地区：[1]中国食品药品检定研究院呼吸道病毒疫苗室,北京100050

出　　处：《微生物学免疫学进展》2017年第3期62-65,共4页Progress In Microbiology and Immunology

基　　金：国家国际科技合作与交流专项(2013DFA31680);国家科技重大专项(2015ZX09101044)

摘　　要：季节性流感和全球性大流感的危害已普遍受到社会各界的关注,而目前的流感治疗药物和流感疫苗在使用上存在一定局限性。siRNA及其介导的RNAi过程自发现以来,其高度特异性和强选择性被广泛应用于抗流感病毒感染的研究中,为流感病毒的防治提供了新思路。而随着研究的深入,siRNA仍面临巨大挑战。对siRNA在抗流感病毒感染中的研究进展进行了综述。Seasonal and global influenza have generally been concerned by the whole society, but some limitations exist in the use of the related drugs or vaccines, siRNA and the processing RNAi have been widely used in research for anti-influen- za virus due to their high speeificity and strong selectivity, which provides a novel investigation in prevention and treatment of influenza. With research going on, there still exists a great challenge in regard to siRNA. The recent progress of siRNA in anti-influenza application is reviewed in this article.

关 键 词：小干扰核糖核酸 RNA干扰 流感病毒 

分 类 号：R511.7[医药卫生—内科学]