子痫前期后部可逆性脑病综合征基底动脉血流动力学的变化  

Basilar Artery Hemodynamic Changes in Preeclamptic Posterior Reversible Encephalopathy Syndrome

作　　者：麦慧[1] 董天发[1] 江魁明[2] 钟熹[3] 陈展航[1] 谭昱[2] 

机构地区：[1]广州医科大学附属第三医院放射科,510150 [2]广东省妇幼保健院放射科,广州511400 [3]广州医科大学附属肿瘤医院放射科,510095

出　　处：《临床放射学杂志》2017年第6期779-782,共4页Journal of Clinical Radiology

基　　金：广东省科技计划项目(粤科规划字[2013]137号-8);广东省医学科学技术研究基金项目(编号:A2015103)

摘　　要：目的应用相位对比磁共振成像(PCMRI)测量子痫前期(PE)基底动脉(BA)血流动力学参数,探讨PE后部可逆性脑病综合征(PRES)与脑MRI正常患者间BA的血流动力学差异。方法对34例PE患者进行常规头颅MRI扫描,根据常规MRI结果分为PRES组和脑MRI正常组,对两组行BA PCMRI扫描,在工作站上利用流体定量(QFLOW)软件进行后处理,T_1-FFE幅度图像上沿BA边缘绘制感兴趣区,软件自动分析得到心动周期内BA的相关血流动力学参数值及时相-流速曲线,记录BA的血管断面面积、平均流速(MV)、平均流量(MF)及血流阻力(RI)。采用SPSS 17.0统计软件比较两组BA血流动力学参数间的差异。结果 PRES组BA的RI低于脑MRI正常组(t=5.61,P<0.05),血管断面面积、MV、MF均显著大于脑MRI正常组(t_(血管断面面积)=4.54,t_(MV)=6.53,t_(MF)=8.41;P值均<0.01)。结论 PE PRES BA血流灌注呈"低阻高排"特征,BA血流高灌注与PRES的发生密切相关。Objective To measure the preeclamptic（ PE） basilar artery（ BA） hemodynamic parameters on phase contrast magnetic resonance imaging（ PCMRI）,and to explore the differences between posterior reversible encephalopathy syndrome（ PRES） and normal brain MRI patients. Methods 34 PE patients underwent conventional MRI scan,and were divided into PRES group and normal brain MRI group according to the results. Both groups underwent BA PCMRI. Using QFLOW software on the workstation for post-processing,the ROI was drawn along the edge of BA in the T_1/FFE amplitude image. Basilar artery hemodynamic parameters and phase-velocity curve in a heartbeat cycle were obtained by automatic analysis software. BA vascular area,mean velocity（ MV）,mean flow（ MF） and resistive index（ RI） were recorded. The differences of BA hemodynamic parameters between the two groups were compared by SPSS17. 0 software. Results RI of BA in PRES group was less than normal brain MRI group（ t = 5. 61,P〈0. 05）. Vascular area,MV,and MF of BA in PRES group were more than normal brain MRI group（ t_（vascular area）= 4. 54,t_（MV）= 6. 53,t_（MF）= 8. 41; all P〈0. 01）. Conclusion The blood perfusion of PE PRES BA is characterized by ＂ low resistance and high discharge＂. BA transition blood flow perfusion is associated with the occurrence of PRES.

关 键 词：子痫前期 后部可逆性脑病综合征 基底动脉 血流动力学 相位对比 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R714.244[医药卫生—诊断学] R747.9[医药卫生—临床医学]